PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| immunoglobulin lambda like polypeptide 1 | ENSG00000128322 | IGLL1 | chr22:23573125-23580308:- | Tbio | 159.093 |
| bromodomain PHD finger transcription factor | ENSG00000171634 | BPTF | chr17:67825524-67984378:+ | Tbio | 43.8678 |
| protein kinase C zeta | ENSG00000067606 | PRKCZ | chr1:2050470-2185395:+ | Tchem | 338.199 |
| hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 | ENSG00000099822 | HCN2 | chr19:589893-617159:+ | Tclin | 131.228 |
| phosphodiesterase 5A | ENSG00000138735 | PDE5A | chr4:119494395-119628991:- | Tclin | 1655.98 |
| membrane bound O-acyltransferase domain containing 2 | ENSG00000143797 | MBOAT2 | chr2:8852690-9003813:- | Tbio | 19.8108 |
| insulin like growth factor 1 | ENSG00000017427 | IGF1 | chr12:102395867-102480645:- | Tbio | 13414.5 |
| plexin B1 | ENSG00000164050 | PLXNB1 | chr3:48403854-48430051:- | Tbio | 194.411 |
| complement C1q like 1 | ENSG00000131094 | C1QL1 | chr17:44959693-44968071:- | Tdark | 265.645 |
| cartilage acidic protein 1 | ENSG00000095713 | CRTAC1 | chr10:97865000-98030828:- | Tbio | 16.2583 |
| EPH receptor A3 | ENSG00000044524 | EPHA3 | chr3:89107524-89482134:+ | Tchem | 91.1925 |
| chromodomain helicase DNA binding protein 9 | ENSG00000177200 | CHD9 | chr16:53055033-53329150:+ | Tbio | 6.27857 |
| CD247 molecule | ENSG00000198821 | CD247 | chr1:167430640-167518610:- | Tbio | 299.463 |
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | ENSG00000127616 | SMARCA4 | chr19:10961001-11065395:+ | Tchem | 527.995 |
| UDP glucuronosyltransferase family 1 member A6 | ENSG00000167165 | UGT1A6 | chr2:233691607-233773300:+ | Tbio | 200.094 |
| transmembrane 4 L six family member 1 | ENSG00000169908 | TM4SF1 | chr3:149369022-149377865:- | Tbio | 98.0234 |
| sphingomyelin phosphodiesterase 3 | ENSG00000103056 | SMPD3 | chr16:68358325-68448688:- | Tbio | 48.124 |
| ornithine aminotransferase | ENSG00000065154 | OAT | chr10:124397303-124418976:- | Tchem | 215.396 |
| ubiquitin conjugating enzyme E2 N | ENSG00000177889 | UBE2N | chr12:93405673-93442262:- | Tbio | 82.2459 |
| nuclear receptor subfamily 1 group I member 2 | ENSG00000144852 | NR1I2 | chr3:119780484-119818485:+ | Tchem | 825.97 |
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