PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
serine peptidase inhibitor, Kunitz type 1ENSG00000166145SPINT1chr15:40844018-40858207:+Tbio101.641
cystatin E/MENSG00000175315CST6chr11:66011841-66013505:+Tbio53.9157
oxytocin/neurophysin I prepropeptideENSG00000101405OXTchr20:3071620-3072517:+Tbio2344.25
pre-mRNA processing factor 4ENSG00000136875PRPF4chr9:113275343-113292905:+Tchem13.9167
BCL2 antagonist/killer 1ENSG00000030110BAK1chr6:33572547-33580293:-Tbio503.757
synaptic vesicle glycoprotein 2AENSG00000159164SV2Achr1:149903318-149917882:-Tclin208.384
frizzled class receptor 6ENSG00000164930FZD6chr8:103298433-103332866:+Tbio24.9798
ATP binding cassette subfamily B member 7ENSG00000131269ABCB7chrX:75053172-75156732:-Tbio309.634
N-myristoyltransferase 1ENSG00000136448NMT1chr17:45051610-45109016:+Tchem172.266
C-terminal Src kinaseENSG00000103653CSKchr15:74782057-74803198:+Tchem354.24
potassium voltage-gated channel subfamily Q member 2ENSG00000075043KCNQ2chr20:63400210-63472677:-Tclin255.786
transient receptor potential cation channel subfamily C member 6ENSG00000137672TRPC6chr11:101451564-101872562:-Tchem491.279
tubulin gamma 1ENSG00000131462TUBG1chr17:42609676-42615234:+Tbio17.41
intercellular adhesion molecule 2ENSG00000108622ICAM2chr17:64002594-64020634:-Tbio117.904
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseENSG00000084774CADchr2:27217390-27243943:+Tchem27.3333
cytochrome P450 family 27 subfamily A member 1ENSG00000135929CYP27A1chr2:218781749-218815293:+Tchem690.741
prostaglandin E receptor 2ENSG00000125384PTGER2chr14:52314305-52328606:+Tclin270.999
carboxylesterase 2ENSG00000172831CES2chr16:66934444-66945096:+Tchem318.29
junctional adhesion molecule 3ENSG00000166086JAM3chr11:134068925-134152001:+Tbio53.9789
secretogranin VENSG00000166922SCG5chr15:32641676-32697098:+Tbio78.9766

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