PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1ENSG00000083444PLOD1chr1:11934205-11975538:+Tbio142.088
solute carrier family 1 member 1ENSG00000106688SLC1A1chr9:4490444-4587469:+Tchem234.655
olfactory receptor family 51 subfamily E member 2ENSG00000167332OR51E2chr11:4680171-4697854:-Tbio20.3746
growth hormone releasing hormoneENSG00000118702GHRHchr20:37251082-37261835:-Tbio2158.53
solute carrier family 11 member 1ENSG00000018280SLC11A1chr2:218382029-218396894:+Tbio310.03
melanocortin 2 receptorENSG00000185231MC2Rchr18:13882044-13915707:-Tclin244.424
stearoyl-CoA desaturase 5ENSG00000145284SCD5chr4:82629539-82798857:-Tchem86.853
reticulon 4ENSG00000115310RTN4chr2:54972187-55112621:-Tbio1090.74
Fc receptor like 3ENSG00000160856FCRL3chr1:157674321-157700857:-Tbio103.632
integrin subunit alpha 5ENSG00000161638ITGA5chr12:54395261-54419460:-Tbio260.246
ATP binding cassette subfamily C member 5ENSG00000114770ABCC5chr3:183919934-184018015:-Tchem103.185
cadherin 5ENSG00000179776CDH5chr16:66366622-66404786:+Tbio619.114
lemur tyrosine kinase 3ENSG00000142235LMTK3chr19:48485271-48513189:-Tbio19.6913
UDP glucuronosyltransferase family 2 member B17ENSG00000197888UGT2B17chr4:68537184-68568527:-Tbio118.499
glycosylphosphatidylinositol specific phospholipase D1ENSG00000112293GPLD1chr6:24424565-24495205:-Tbio716.109
peroxisome proliferator activated receptor deltaENSG00000112033PPARDchr6:35342558-35428191:+Tchem507.398
lysine methyltransferase 5CENSG00000133247SUV420H2chr19:55339853-55348120:+Tdark9.86667
Wnt family member 6ENSG00000115596WNT6chr2:218859821-218874233:+Tbio23.4914
UDP glucuronosyltransferase family 2 member B4ENSG00000156096UGT2B4chr4:69480165-69526014:-Tbio57.6087
fructose-bisphosphatase 1ENSG00000165140FBP1chr9:94603133-94640249:-Tchem113.851

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