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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
CD209 molecule	ENSG00000090659	CD209	chr19:7739994-7747564:-	Tbio	353.396
lysyl-tRNA synthetase 1	ENSG00000065427	KARS	chr16:75627474-75648643:-	Tchem	139.113
serine/threonine kinase 31	ENSG00000196335	STK31	chr7:23710167-23832513:+	Tbio	7.16848
3-hydroxybutyrate dehydrogenase 1	ENSG00000161267	BDH1	chr3:197509783-197573323:-	Tbio	48.4109
serpin family A member 5	ENSG00000188488	SERPINA5	chr14:94561442-94593120:+	Tbio	280.407
killer cell lectin like receptor B1	ENSG00000111796	KLRB1	chr12:9594551-9607886:-	Tbio	163.607
CD151 molecule (Raph blood group)	ENSG00000177697	CD151	chr11:832843-839831:+	Tbio	204.732
hedgehog interacting protein	ENSG00000164161	HHIP	chr4:144646021-144745271:+	Tbio	62.6996
eukaryotic translation initiation factor 2 alpha kinase 3	ENSG00000172071	EIF2AK3	chr2:88556741-88627576:-	Tchem	585.887
C-C motif chemokine ligand 3	ENSG00000277632	CCL3	chr17:36088256-36090169:-	Tbio	855.223
aldehyde dehydrogenase 3 family member A1	ENSG00000108602	ALDH3A1	chr17:19737984-19748943:-	Tchem	117.014
C-C motif chemokine ligand 5	ENSG00000271503	CCL5	chr17:35871491-35880793:-	Tchem	1704.78
proteasome assembly chaperone 3	ENSG00000157778	PSMG3	chr7:1567330-1571005:-	Tchem	13.5167
doublecortin like kinase 2	ENSG00000170390	DCLK2	chr4:150078274-150257457:+	Tchem	6.51026
Nik related kinase	ENSG00000123572	NRK	chrX:105822543-105958610:+	Tdark	3.075
TNF receptor superfamily member 13C	ENSG00000159958	TNFRSF13C	chr22:41922023-41926818:-	Tbio	132.593
nerve growth factor receptor	ENSG00000064300	NGFR	chr17:49495293-49515017:+	Tclin	711.806
glutamyl aminopeptidase	ENSG00000138792	ENPEP	chr4:110365733-110565285:+	Tchem	745.901
transporter 1, ATP binding cassette subfamily B member	ENSG00000168394	TAP1	chr6:32845209-32853978:-	Tbio	509.554
cholesteryl ester transfer protein	ENSG00000087237	CETP	chr16:56961850-56983845:+	Tchem	1517.84

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