PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
transcription factor 19ENSG00000137310TCF19chr6:31158542-31167159:+Tbio130.104
dual specificity phosphatase 10ENSG00000143507DUSP10chr1:221701424-221742176:-Tbio24.5158
glutamyl-prolyl-tRNA synthetase 1ENSG00000136628EPRSchr1:219968601-220046658:-Tchem44.7782
aldo-keto reductase family 1 member B10ENSG00000198074AKR1B10chr7:134527592-134541408:+Tchem140.326
kallikrein related peptidase 14ENSG00000129437KLK14chr19:51077495-51084245:-Tchem36.6404
heparin binding growth factorENSG00000143321HDGFchr1:156742107-156766925:-Tbio125.176
solute carrier family 22 member 2ENSG00000112499SLC22A2chr6:160171061-160277638:-Tchem170.489
PHD finger protein 20 like 1ENSG00000129292PHF20L1chr8:132775358-132848807:+Tdark1.79167
frizzled class receptor 4ENSG00000174804FZD4chr11:86945679-86955391:-Tbio70.1864
protein tyrosine kinase 7 (inactive)ENSG00000112655PTK7chr6:43076268-43161719:+Tbio123.984
ATP binding cassette subfamily C member 8ENSG00000006071ABCC8chr11:17392885-17476845:-Tclin565.031
calcium voltage-gated channel subunit alpha1 EENSG00000198216CACNA1Echr1:181413102-181808084:+Tbio194.778
slit guidance ligand 2ENSG00000145147SLIT2chr4:20253260-20620561:+Tbio126.842
troponin I3, cardiac typeENSG00000129991TNNI3chr19:55151767-55157773:-Tbio1640.46
prostaglandin D2 synthaseENSG00000107317PTGDSchr9:136977505-136985435:+Tbio919.105
ubiquitin specific peptidase 8ENSG00000138592USP8chr15:50424380-50514419:+Tbio37.1897
superoxide dismutase 3ENSG00000109610SOD3chr4:24789912-24800842:+Tbio326.299
aldo-keto reductase family 1 member C2ENSG00000151632AKR1C2chr10:4922564-5135226:-Tchem154.136
UDP glucuronosyltransferase family 1 member A9ENSG00000241119UGT1A9chr2:233671853-233773300:+Tbio232.745
vesicle associated membrane protein 2ENSG00000220205VAMP2chr17:8159149-8163546:-Tbio200.33

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