PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
collagen type XVII alpha 1 chainENSG00000065618COL17A1chr10:104031286-104086002:-Tbio519.52
parathyroid hormone 1 receptorENSG00000160801PTH1Rchr3:46877746-46903799:+Tclin296.108
furin, paired basic amino acid cleaving enzymeENSG00000140564FURINchr15:90868592-90883458:+Tchem782.578
cytokine like 1ENSG00000170891CYTL1chr4:5014586-5019472:-Tbio432.844
nuclear receptor subfamily 4 group A member 1ENSG00000123358NR4A1chr12:52022832-52059507:+Tbio2018.75
four-jointed box kinase 1ENSG00000179431FJX1chr11:35618419-35620868:+Tbio2.23707
CD6 moleculeENSG00000013725CD6chr11:60971680-61020377:+Tbio521.116
histidine decarboxylaseENSG00000140287HDCchr15:50241947-50266026:-Tbio469
mitogen-activated protein kinase kinase 7ENSG00000076984MAP2K7chr19:7903843-7914478:+Tchem1751.26
cytochrome P450 family 11 subfamily A member 1ENSG00000140459CYP11A1chr15:74337759-74367740:-Tclin574.546
colony stimulating factor 1ENSG00000184371CSF1chr1:109910242-109930992:+Tbio1302.85
regenerating family member 1 alphaENSG00000115386REG1Achr2:79120362-79123419:+Tbio511.937
ELAV like RNA binding protein 1ENSG00000066044ELAVL1chr19:7958579-8445041:-Tchem433.047
peptidylglycine alpha-amidating monooxygenaseENSG00000145730PAMchr5:102753981-103031105:+Tchem560.562
nucleoporin 153ENSG00000124789NUP153chr6:17615035-17706834:-Tbio87.9075
hypoxia up-regulated 1ENSG00000149428HYOU1chr11:119044189-119057202:-Tbio72.7655
C-C motif chemokine ligand 4ENSG00000275302CCL4chr17:36103590-36105621:+Tbio1228.59
defensin beta 1ENSG00000164825DEFB1chr8:6870575-6878022:-Tbio339.432
prolactin induced proteinENSG00000159763PIPchr7:143132077-143139746:+Tbio940.577
thioredoxin reductase 1ENSG00000198431TXNRD1chr12:104215779-104350305:+Tclin747.895

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