PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
leucine rich glioma inactivated 1ENSG00000108231LGI1chr10:93757809-93798174:+Tbio235.919
protein tyrosine phosphatase non-receptor type 2ENSG00000175354PTPN2chr18:12785478-12929643:-Tchem169.227
glutathione S-transferase alpha 1ENSG00000243955GSTA1chr6:52791664-52803910:-Tchem287.283
FLVCR heme transporter 1ENSG00000162769FLVCR1chr1:212858255-212899363:+Tbio123.544
mitogen-activated protein kinase kinase 4ENSG00000065559MAP2K4chr17:12020824-12143830:+Tchem224.612
proprotein convertase subtilisin/kexin type 1ENSG00000175426PCSK1chr5:96390415-96434143:-Tchem630.211
cytochrome p450 oxidoreductaseENSG00000127948PORchr7:75899200-75986855:+Tbio1006.33
alpha-2-macroglobulinENSG00000175899A2Mchr12:9067664-9116229:-Tbio2462.93
survival of motor neuron 2, centromericENSG00000205571SMN2chr5:70049612-70078522:+Tbio300.788
hydroxysteroid 17-beta dehydrogenase 2ENSG00000086696HSD17B2chr16:82035004-82098534:+Tchem94.0072
notch receptor 4ENSG00000204301NOTCH4chr6:32194843-32224067:-Tchem176.234
bradykinin receptor B1ENSG00000100739BDKRB1chr14:96255824-96268967:+Tchem236.749
collagen type XI alpha 2 chainENSG00000204248COL11A2chr6:33162681-33192499:-Tbio406.695
pyrimidinergic receptor P2Y6ENSG00000171631P2RY6chr11:73264505-73298617:+Tchem161.581
ST3 beta-galactoside alpha-2,3-sialyltransferase 4ENSG00000110080ST3GAL4chr11:126355640-126440344:+Tbio133.465
CYLD lysine 63 deubiquitinaseENSG00000083799CYLDchr16:50742050-50801935:+Tbio288.252
apolipoprotein MENSG00000204444APOMchr6:31652416-31658210:+Tbio126.574
calcium voltage-gated channel auxiliary subunit alpha2delta 3ENSG00000157445CACNA2D3chr3:54122547-55074557:+Tbio14.3635
mitogen-activated protein kinase 7ENSG00000166484MAPK7chr17:19377721-19383544:+Tbio202.26
secretoglobin family 2A member 1ENSG00000124939SCGB2A1chr11:62208668-62213939:+Tbio205.427

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