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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
discoidin domain receptor tyrosine kinase 1	ENSG00000204580	DDR1	chr6:30876421-30900156:+	Tchem	151.045
DNA ligase 1	ENSG00000105486	LIG1	chr19:48115445-48170603:-	Tchem	60.9067
teneurin transmembrane protein 1	ENSG00000009694	TENM1	chrX:124375903-124963817:-	Tbio	3405.12
uncoupling protein 3	ENSG00000175564	UCP3	chr11:74000281-74009435:-	Tbio	293.447
acetyl-CoA carboxylase beta	ENSG00000076555	ACACB	chr12:109116595-109268226:+	Tchem	86.2127
tubulin alpha 1b	ENSG00000123416	TUBA1B	chr12:49127782-49131397:-	Tchem	329.351
nodal growth differentiation factor	ENSG00000156574	NODAL	chr10:70432315-70447951:-	Tbio	215.36
glutathione peroxidase 3	ENSG00000211445	GPX3	chr5:151020438-151028993:+	Tbio	303.652
cyclin dependent kinase 5	ENSG00000164885	CDK5	chr7:151053812-151058530:-	Tchem	542.824
PR/SET domain 16	ENSG00000142611	PRDM16	chr1:3069168-3438621:+	Tbio	96.2533
ATPase phospholipid transporting 8B1	ENSG00000081923	ATP8B1	chr18:57646426-57803101:-	Tbio	189.749
CD58 molecule	ENSG00000116815	CD58	chr1:116514535-116571039:-	Tbio	331.948
thrombomodulin	ENSG00000178726	THBD	chr20:23045633-23049741:-	Tbio	1211.36
TNF receptor superfamily member 17	ENSG00000048462	TNFRSF17	chr16:11965107-11968068:+	Tbio	107.124
interleukin 23 subunit alpha	ENSG00000110944	IL23A	chr12:56334174-56340410:+	Tclin	904.094
deleted in malignant brain tumors 1	ENSG00000187908	DMBT1	chr10:122560665-122643736:+	Tbio	221.528
azurocidin 1	ENSG00000172232	AZU1	chr19:825097-832018:+	Tbio	161.21
nuclear receptor subfamily 4 group A member 3	ENSG00000119508	NR4A3	chr9:99821855-99866891:+	Tbio	205.672
prostaglandin I2 synthase	ENSG00000124212	PTGIS	chr20:49503874-49568146:-	Tbio	138.853
mitogen-activated protein kinase kinase kinase 5	ENSG00000197442	MAP3K5	chr6:136557047-136792518:-	Tchem	288.636

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