PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 26 member 3ENSG00000091138SLC26A3chr7:107765467-107803225:-Tbio298.801
Fc fragment of IgE receptor IIENSG00000104921FCER2chr19:7688758-7702146:-Tchem958.458
tachykinin receptor 1ENSG00000115353TACR1chr2:75046463-75199700:-Tclin925.004
serine/threonine kinase 3ENSG00000104375STK3chr8:98401403-98942827:-Tchem55.358
SIK family kinase 3ENSG00000160584SIK3chr11:116843402-117098437:-Tchem4.15516
ADAM metallopeptidase domain 8ENSG00000151651ADAM8chr10:133262403-133276868:-Tchem76.2945
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3ENSG00000074370ATP2A3chr17:3923870-3964464:-Tbio177.453
biglycanENSG00000182492BGNchrX:153494939-153509554:+Tbio502.016
glutamate decarboxylase 1ENSG00000128683GAD1chr2:170813213-170861151:+Tbio975.074
laminin subunit alpha 3ENSG00000053747LAMA3chr18:23689443-23955066:+Tbio85.4021
D-amino acid oxidaseENSG00000110887DAOchr12:108858932-108901043:+Tchem447.504
FKBP prolyl isomerase 5ENSG00000096060FKBP5chr6:35573585-35728583:-Tchem220.478
granulin precursorENSG00000030582GRNchr17:44345086-44353102:+Tbio940.88
cholinergic receptor nicotinic alpha 4 subunitENSG00000101204CHRNA4chr20:63343223-63378401:-Tclin1723.69
interleukin 7ENSG00000104432IL7chr8:78675743-78805523:-Tbio875.217
fibrinogen alpha chainENSG00000171560FGAchr4:154583126-154590766:-Tbio542.646
proteasome 26S subunit, ATPase 2ENSG00000161057PSMC2chr7:103344254-103369395:+Tbio16.4524
ATP binding cassette subfamily A member 3ENSG00000167972ABCA3chr16:2275881-2340746:-Tbio162.087
adrenomedullin 2ENSG00000128165ADM2chr22:50481556-50486440:+Tbio162.607
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideENSG00000196344ADH7chr4:99412261-99435737:-Tchem125.276

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