PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
EPH receptor A7ENSG00000135333EPHA7chr6:93240020-93419547:-Tchem44.926
SET domain containing 1A, histone lysine methyltransferaseENSG00000099381SETD1Achr16:30957294-30985116:+Tbio238.461
secreted frizzled related protein 4ENSG00000106483SFRP4chr7:37905932-38025695:-Tbio82.3282
solute carrier family 4 member 4ENSG00000080493SLC4A4chr4:71187286-71572087:+Tbio139.236
apoptosis inducing factor mitochondria associated 1ENSG00000156709AIFM1chrX:130129362-130165887:-Tbio112.613
contactin 2ENSG00000184144CNTN2chr1:205043197-205078499:+Tbio1014.16
glutathione peroxidase 2ENSG00000176153GPX2chr14:64939152-64942905:-Tbio83.395
solute carrier family 3 member 1ENSG00000138079SLC3A1chr2:44275458-44321494:+Tbio138.944
surfactant protein CENSG00000168484SFTPCchr8:22156913-22164479:+Tbio442.303
nuclear receptor corepressor 2ENSG00000196498NCOR2chr12:124324415-124567589:-Tchem226.54
serine/threonine/tyrosine kinase 1ENSG00000060140STYK1chr12:10618939-10674318:-Tbio133.972
transglutaminase 2ENSG00000198959TGM2chr20:38127387-38166578:-Tchem1720.06
calcium voltage-gated channel subunit alpha1 DENSG00000157388CACNA1Dchr3:53494656-53813733:+Tclin106.127
apoptotic peptidase activating factor 1ENSG00000120868APAF1chr12:98645141-98735433:+Tbio341.434
actinin alpha 1ENSG00000072110ACTN1chr14:68874143-68979440:-Tbio660.235
ADCYAP receptor type IENSG00000078549ADCYAP1R1chr7:31052461-31111479:+Tchem168.004
purinergic receptor P2X 7ENSG00000089041P2RX7chr12:121132819-121188032:+Tchem787.136
DNA topoisomerase II betaENSG00000077097TOP2Bchr3:25597905-25664907:-Tchem203.148
apurinic/apyrimidinic endodeoxyribonuclease 1ENSG00000100823APEX1chr14:20455191-20457772:+Tchem1193.94
microtubule associated serine/threonine kinase likeENSG00000120539MASTLchr10:27154824-27186924:+Tbio28.6095

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