PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
C-C motif chemokine ligand 18ENSG00000275385CCL18chr17:36064280-36072032:+Tbio206.832
O-6-methylguanine-DNA methyltransferaseENSG00000170430MGMTchr10:129467184-129768007:+Tchem2002.36
ribonuclease LENSG00000135828RNASELchr1:182573634-182589256:-Tchem397.119
lymphocyte antigen 6 family member KENSG00000160886LY6Kchr8:142700111-142705127:+Tbio15.9667
protein kinase AMP-activated catalytic subunit alpha 2ENSG00000162409PRKAA2chr1:56645322-56715335:+Tchem779.173
metallothionein 3ENSG00000087250MT3chr16:56589074-56591088:+Tbio308.195
protein kinase cGMP-dependent 1ENSG00000185532PRKG1chr10:50991358-52298350:+Tchem463.159
TNF receptor superfamily member 8ENSG00000120949TNFRSF8chr1:12063377-12144207:+Tclin2042.15
serpin family C member 1ENSG00000117601SERPINC1chr1:173903804-173917378:-Tclin4170.72
phospholipase C gamma 2ENSG00000197943PLCG2chr16:81739097-81962693:+Tchem116.046
cystatin SAENSG00000170369CST2chr20:23823769-23826731:-Tbio43.956
DNA methyltransferase 3 alphaENSG00000119772DNMT3Achr2:25227855-25342590:-Tclin435.838
TIMP metallopeptidase inhibitor 4ENSG00000157150TIMP4chr3:12153051-12159351:-Tbio89.6658
dual specificity phosphatase 9ENSG00000130829DUSP9chrX:153642492-153651326:+Tbio15.2949
potassium calcium-activated channel subfamily N member 3ENSG00000143603KCNN3chr1:154697455-154870280:-Tchem156.526
natriuretic peptide receptor 3ENSG00000113389NPR3chr5:32689070-32791724:+Tchem149.574
perforin 1ENSG00000180644PRF1chr10:70597348-70602775:-Tchem382.045
protein C receptorENSG00000101000PROCRchr20:35172073-35177362:+Tbio371.636
thiopurine S-methyltransferaseENSG00000137364TPMTchr6:18128311-18155074:-Tchem911.769
multimerin 1ENSG00000138722MMRN1chr4:89879532-89954629:+Tbio548.475

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