PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
tubulin alpha 1cENSG00000167553TUBA1Cchr12:49188736-49274603:+Tchem3.54924
fibrillin 2ENSG00000138829FBN2chr5:128257909-128659185:-Tbio175.878
chitinase 1ENSG00000133063CHIT1chr1:203212827-203273641:-Tbio290.594
glutamate-cysteine ligase catalytic subunitENSG00000001084GCLCchr6:53497341-53616970:-Tchem453.278
nuclear receptor binding SET domain protein 2ENSG00000109685WHSC1chr4:1871424-1982207:+Tbio98.9976
activin A receptor type 2BENSG00000114739ACVR2Bchr3:38453851-38493142:+Tchem60.1815
ADAM metallopeptidase with thrombospondin type 1 motif 5ENSG00000154736ADAMTS5chr21:26917912-26966513:-Tchem122.368
interleukin 15ENSG00000164136IL15chr4:141636599-141733987:+Tbio1041.41
cryptochrome circadian regulator 2ENSG00000121671CRY2chr11:45847118-45883248:+Tbio83.3686
lysosomal associated membrane protein 3ENSG00000078081LAMP3chr3:183122213-183163839:-Tbio151.181
pre-mRNA processing factor 4BENSG00000112739PRPF4Bchr6:4021267-4064983:+Tchem24.3429
lactotransferrinENSG00000012223LTFchr3:46435645-46485234:-Tbio348.692
latexinENSG00000079257LXNchr3:158645822-158672693:-Tbio612.933
proteolipid protein 1ENSG00000123560PLP1chrX:103773718-103792619:+Tbio721.483
protein tyrosine phosphatase non-receptor type 14ENSG00000152104PTPN14chr1:214348696-214552449:-Tbio44.3477
TNF receptor superfamily member 19ENSG00000127863TNFRSF19chr13:23570370-23676104:+Tbio151.765
matrix metallopeptidase 28ENSG00000271447MMP28chr17:35756249-35795707:-Tbio42.7213
sphingosine-1-phosphate receptor 3ENSG00000213694S1PR3chr9:88991447-89005010:+Tclin86.6797
amyloid beta precursor like protein 1ENSG00000105290APLP1chr19:35867899-35879791:+Tbio61.404
mannan binding lectin serine peptidase 1ENSG00000127241MASP1chr3:187217285-187292022:-Tbio165.205

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