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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
FKBP prolyl isomerase 4	ENSG00000004478	FKBP4	chr12:2794953-2805423:+	Tchem	166.486
fibrinogen gamma chain	ENSG00000171557	FGG	chr4:154604134-154612967:-	Tbio	163.797
ectonucleotide pyrophosphatase/phosphodiesterase 1	ENSG00000197594	ENPP1	chr6:131808016-131895155:+	Tchem	357.358
cytochrome P450 family 2 subfamily A member 6	ENSG00000255974	CYP2A6	chr19:40843538-40882210:-	Tchem	666.442
peptidyl arginine deiminase 1	ENSG00000142623	PADI1	chr1:17205126-17246005:+	Tchem	561.565
inducible T cell costimulator	ENSG00000163600	ICOS	chr2:203936748-203961577:+	Tbio	219.199
monoamine oxidase B	ENSG00000069535	MAOB	chrX:43766611-43882447:-	Tclin	1519.37
macrophage receptor with collagenous structure	ENSG00000019169	MARCO	chr2:118942166-118994660:+	Tbio	162.061
carnitine palmitoyltransferase 1B	ENSG00000205560	CPT1B	chr22:50568861-50578465:-	Tchem	183.92
proteoglycan 4	ENSG00000116690	PRG4	chr1:186296279-186314562:+	Tbio	252.762
nuclear receptor subfamily 4 group A member 2	ENSG00000153234	NR4A2	chr2:156324432-156342348:-	Tchem	263.74
integrin subunit beta 5	ENSG00000082781	ITGB5	chr3:124761948-124901418:-	Tbio	40.7551
BCL2 associated agonist of cell death	ENSG00000002330	BAD	chr11:64269830-64284704:-	Tchem	2910.25
chondroitin sulfate proteoglycan 4	ENSG00000173546	CSPG4	chr15:75674322-75712848:-	Tbio	379.692
frizzled class receptor 2	ENSG00000180340	FZD2	chr17:44557459-44559570:+	Tbio	24.5977
15-hydroxyprostaglandin dehydrogenase	ENSG00000164120	HPGD	chr4:174490177-174523154:-	Tchem	220.577
aquaporin 5	ENSG00000161798	AQP5	chr12:49961870-49965681:+	Tbio	188.73
cadherin 13	ENSG00000140945	CDH13	chr16:82626803-83800640:+	Tbio	208.736
complement factor properdin	ENSG00000126759	CFP	chrX:47624213-47630305:-	Tbio	431.953
kelch like family member 6	ENSG00000172578	KLHL6	chr3:183487531-183555689:-	Tbio	1.41374

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