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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
apolipoprotein C2	ENSG00000234906	APOC2	chr19:44946035-44949565:+	Tbio	329.942
glycophorin C (Gerbich blood group)	ENSG00000136732	GYPC	chr2:126655933-126696675:+	Tbio	427.724
solute carrier family 14 member 1 (Kidd blood group)	ENSG00000141469	SLC14A1	chr18:45724127-45752520:+	Tchem	131.919
S100 calcium binding protein A12	ENSG00000163221	S100A12	chr1:153373706-153375649:-	Tbio	323.029
purine nucleoside phosphorylase	ENSG00000198805	PNP	chr14:20468954-20477094:+	Tclin	350.284
C-C motif chemokine ligand 26	ENSG00000006606	CCL26	chr7:75769533-75789896:-	Tbio	217.715
tudor and KH domain containing	ENSG00000182134	TDRKH	chr1:151770107-151791416:-	Tdark	2.4943
collagen type XVIII alpha 1 chain	ENSG00000182871	COL18A1	chr21:45405137-45513720:+	Tbio	819.952
histamine receptor H1	ENSG00000196639	HRH1	chr3:11137093-11263557:+	Tclin	148.736
bone morphogenetic protein receptor type 1A	ENSG00000107779	BMPR1A	chr10:86756650-86932838:+	Tchem	133.326
calpain 3	ENSG00000092529	CAPN3	chr15:42359500-42412318:+	Tbio	298.381
G protein-coupled receptor kinase 2	ENSG00000173020	ADRBK1	chr11:67266410-67286556:+	Tchem	385.461
CD177 molecule	ENSG00000204936	CD177	chr19:43353659-43363172:+	Tbio	497.553
SLAM family member 7	ENSG00000026751	SLAMF7	chr1:160739057-160754821:+	Tclin	469.818
endothelin receptor type A	ENSG00000151617	EDNRA	chr4:147480917-147544954:+	Tclin	1930.88
FYN proto-oncogene, Src family tyrosine kinase	ENSG00000010810	FYN	chr6:111660332-111873452:-	Tclin	672.116
midkine	ENSG00000110492	MDK	chr11:46380756-46383837:+	Tchem	121.16
perilipin 2	ENSG00000147872	PLIN2	chr9:19108375-19149290:-	Tbio	226.15
PR/SET domain 15	ENSG00000141956	PRDM15	chr21:41798225-41879482:-	Tdark	4.07692
natriuretic peptide A	ENSG00000175206	NPPA	chr1:11845709-11848345:-	Tchem	1992.28

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