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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
Fc fragment of IgG receptor IIa	ENSG00000143226	FCGR2A	chr1:161505430-161524013:+	Tbio	588.665
splicing factor 3b subunit 3	ENSG00000189091	SF3B3	chr16:70523788-70577670:+	Tchem	13.1546
somatostatin receptor 1	ENSG00000139874	SSTR1	chr14:38207999-38213067:+	Tclin	105.555
interleukin 7 receptor	ENSG00000168685	IL7R	chr5:35852695-35879603:+	Tbio	414.848
proteasome 20S subunit beta 5	ENSG00000100804	PSMB5	chr14:23016543-23035230:-	Tclin	47.6493
fibrinogen beta chain	ENSG00000171564	FGB	chr4:154562956-154571086:+	Tbio	15551.7
prostaglandin E receptor 1	ENSG00000160951	PTGER1	chr19:14472466-14475362:-	Tclin	198.098
death associated protein kinase 1	ENSG00000196730	DAPK1	chr9:87497228-87708633:+	Tchem	307.555
SUMO1 activating enzyme subunit 1	ENSG00000142230	SAE1	chr19:47113274-47210636:+	Tbio	22.8948
cytochrome P450 family 2 subfamily C member 9	ENSG00000138109	CYP2C9	chr10:94938658-94989390:+	Tchem	1943.45
tribbles pseudokinase 1	ENSG00000173334	TRIB1	chr8:125430321-125438405:+	Tbio	57.8208
vinculin	ENSG00000035403	VCL	chr10:73995193-74121363:+	Tbio	1025.95
phospholipase A2 group VI	ENSG00000184381	PLA2G6	chr22:38111495-38205690:-	Tchem	228.358
SPT16 homolog, facilitates chromatin remodeling subunit	ENSG00000092201	SUPT16H	chr14:21351472-21384266:-	Tbio	28.0762
toll like receptor 5	ENSG00000187554	TLR5	chr1:223109406-223143282:-	Tbio	285.277
gastrin releasing peptide receptor	ENSG00000126010	GRPR	chrX:16123556-16153021:+	Tchem	234.603
solute carrier family 5 member 1	ENSG00000100170	SLC5A1	chr22:32043032-32113029:+	Tchem	321.587
inhibin subunit alpha	ENSG00000123999	INHA	chr2:219569162-219575713:+	Tbio	322.718
microseminoprotein beta	ENSG00000263639	MSMB	chr10:46033307-46046269:-	Tbio	626.239
LDL receptor related protein 8	ENSG00000157193	LRP8	chr1:53242364-53328070:-	Tbio	93.3197

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