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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
DBF4 zinc finger	ENSG00000006634	DBF4	chr7:87876216-87909541:+	Tbio	43.7317
tet methylcytosine dioxygenase 1	ENSG00000138336	TET1	chr10:68560656-68694482:+	Tbio	166.167
cytochrome P450 family 2 subfamily B member 6	ENSG00000197408	CYP2B6	chr19:40991299-41018398:+	Tchem	1809.76
inhibitor of growth family member 3	ENSG00000071243	ING3	chr7:120950749-120977216:+	Tbio	12.8968
high mobility group box 2	ENSG00000164104	HMGB2	chr4:173331695-173335125:-	Tbio	166.989
prostaglandin-endoperoxide synthase 1	ENSG00000095303	PTGS1	chr9:122370530-122395703:+	Tclin	766.854
Wnt family member 10A	ENSG00000135925	WNT10A	chr2:218880363-218899581:+	Tbio	85.6404
protein tyrosine phosphatase non-receptor type 11	ENSG00000179295	PTPN11	chr12:112418351-112509913:+	Tchem	958.993
serum/glucocorticoid regulated kinase 1	ENSG00000118515	SGK1	chr6:134169246-134318112:-	Tchem	290.798
dystonin	ENSG00000151914	DST	chr6:56457987-56954628:-	Tbio	512.461
transthyretin	ENSG00000118271	TTR	chr18:31591726-31599021:+	Tclin	2584.04
inositol polyphosphate phosphatase like 1	ENSG00000165458	INPPL1	chr11:72223701-72239105:+	Tchem	126.349
RAR related orphan receptor A	ENSG00000069667	RORA	chr15:60488284-61229319:-	Tchem	147.139
CDC like kinase 2	ENSG00000176444	CLK2	chr1:155262868-155278491:-	Tchem	19.5024
C-C motif chemokine ligand 21	ENSG00000137077	CCL21	chr9:34709005-34710124:-	Tbio	305.049
dihydrolipoamide dehydrogenase	ENSG00000091140	DLD	chr7:107890970-107931730:+	Tbio	512.755
PMS1 homolog 2, mismatch repair system component	ENSG00000122512	PMS2	chr7:5973239-6009125:-	Tbio	327.745
ketohexokinase	ENSG00000138030	KHK	chr2:27086747-27100772:+	Tchem	108.167
regenerating family member 3 alpha	ENSG00000172016	REG3A	chr2:79157003-79159753:-	Tbio	1637.81
beta-secretase 1	ENSG00000186318	BACE1	chr11:117285207-117316259:-	Tchem	1007.32

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