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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
olfactory receptor family 51 subfamily E member 1	ENSG00000180785	OR51E1	chr11:4643420-4655488:+	Tbio	10.6881
ghrelin and obestatin prepropeptide	ENSG00000157017	GHRL	chr3:10285675-10292947:-	Tchem	574.819
TNF receptor superfamily member 25	ENSG00000215788	TNFRSF25	chr1:6461151-6466195:-	Tbio	889.851
UDP glucuronosyltransferase family 2 member B7	ENSG00000171234	UGT2B7	chr4:69051363-69112987:+	Tchem	308.981
prion protein	ENSG00000171867	PRNP	chr20:4686236-4701590:+	Tchem	5232.48
heat shock protein 90 beta family member 1	ENSG00000166598	HSP90B1	chr12:103930107-103953645:+	Tchem	378.722
geranylgeranyl diphosphate synthase 1	ENSG00000152904	GGPS1	chr1:235327350-235344532:+	Tchem	38.2929
receptor tyrosine kinase like orphan receptor 1	ENSG00000185483	ROR1	chr1:63774022-64181498:+	Tbio	98.4702
cellular communication network factor 1	ENSG00000142871	CYR61	chr1:85580761-85583962:+	Tbio	286.295
CD276 molecule	ENSG00000103855	CD276	chr15:73683966-73714518:+	Tbio	144.78
galectin 3 binding protein	ENSG00000108679	LGALS3BP	chr17:78971238-78980109:-	Tbio	179.033
nuclear factor of activated T cells 1	ENSG00000131196	NFATC1	chr18:79395856-79529325:+	Tbio	275.552
amyloid P component, serum	ENSG00000132703	APCS	chr1:159587825-159588865:+	Tbio	511.393
thyroid hormone receptor beta	ENSG00000151090	THRB	chr3:24117160-24495282:-	Tclin	407.029
jagged canonical Notch ligand 1	ENSG00000101384	JAG1	chr20:10637684-10674107:-	Tbio	477.41
protein tyrosine kinase 6	ENSG00000101213	PTK6	chr20:63528001-63537370:-	Tchem	107.853
IL2 inducible T cell kinase	ENSG00000113263	ITK	chr5:157142933-157255191:+	Tclin	654.324
fucosyltransferase 2	ENSG00000176920	FUT2	chr19:48695971-48705950:+	Tbio	527.943
apolipoprotein B mRNA editing enzyme catalytic subunit 3G	ENSG00000239713	APOBEC3G	chr22:39040961-39087743:+	Tbio	538.687
caspase 4	ENSG00000196954	CASP4	chr11:104942866-104969436:-	Tchem	143.111

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