PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
tenascin RENSG00000116147TNRchr1:175315194-175743770:-Tbio118.783
carbamoyl-phosphate synthase 1ENSG00000021826CPS1chr2:210477682-210679107:+Tclin378.576
ADAM metallopeptidase with thrombospondin type 1 motif 4ENSG00000158859ADAMTS4chr1:161184308-161199056:-Tchem149.969
estrogen related receptor gammaENSG00000196482ESRRGchr1:216503246-217137755:-Tchem87.8137
bone morphogenetic protein 4ENSG00000125378BMP4chr14:53949736-53958761:-Tchem730.478
lysine demethylase 5BENSG00000117139KDM5Bchr1:202724491-202809470:-Tchem74.03
steroid sulfataseENSG00000101846STSchrX:7219456-7354810:+Tchem1212.02
toll like receptor 1ENSG00000174125TLR1chr4:38790677-38856817:-Tbio204.748
serpin family D member 1ENSG00000099937SERPIND1chr22:20773879-20787720:+Tbio387.078
thromboxane A2 receptorENSG00000006638TBXA2Rchr19:3594506-3606840:-Tclin273.713
fibroblast growth factor 7ENSG00000140285FGF7chr15:49423096-49488775:+Tbio495.08
CD7 moleculeENSG00000173762CD7chr17:82314868-82317602:-Tbio532.642
solute carrier family 6 member 2ENSG00000103546SLC6A2chr16:55655604-55706192:+Tclin558.082
serpin family B member 4ENSG00000206073SERPINB4chr18:63637259-63644298:-Tbio63.8996
neurotensinENSG00000133636NTSchr12:85874295-85882992:+Tbio910.677
interleukin 1 receptor associated kinase 1ENSG00000184216IRAK1chrX:154010500-154019980:-Tchem242.309
kelch like ECH associated protein 1ENSG00000079999KEAP1chr19:10486120-10503741:-Tclin408.436
defensin beta 4AENSG00000171711DEFB4Achr8:7894629-7896711:+Tbio517.354
glucuronidase betaENSG00000169919GUSBchr7:65960684-65982314:-Tchem234.478
potassium two pore domain channel subfamily K member 5ENSG00000164626KCNK5chr6:39188973-39229450:-Tbio188.855

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