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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
p21 (RAC1) activated kinase 1	ENSG00000149269	PAK1	chr11:77321707-77474635:-	Tchem	357.053
BMP and activin membrane bound inhibitor	ENSG00000095739	BAMBI	chr10:28677342-28682939:+	Tbio	51.9357
myosin light chain kinase	ENSG00000065534	MYLK	chr3:123610049-123884331:-	Tchem	649.687
inhibin subunit beta E	ENSG00000139269	INHBE	chr12:57452323-57459280:+	Tbio	447.709
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	ENSG00000138363	ATIC	chr2:215311817-215349773:+	Tchem	191.453
extracellular matrix protein 1	ENSG00000143369	ECM1	chr1:150508062-150513789:+	Tbio	124.947
phospholipase A2 group X	ENSG00000069764	PLA2G10	chr16:14672545-14694669:-	Tchem	182.597
cytochrome P450 family 19 subfamily A member 1	ENSG00000137869	CYP19A1	chr15:51208057-51338610:-	Tclin	1509.37
ATP binding cassette subfamily B member 4	ENSG00000005471	ABCB4	chr7:87401697-87480435:-	Tbio	496.179
CD3g molecule	ENSG00000160654	CD3G	chr11:118344344-118355161:+	Tclin	107.299
histone deacetylase 4	ENSG00000068024	HDAC4	chr2:239048168-239401654:-	Tclin	202.835
neuronal growth regulator 1	ENSG00000172260	NEGR1	chr1:71395940-72282734:-	Tbio	35.8785
thyroid hormone receptor alpha	ENSG00000126351	THRA	chr17:40058290-40093867:+	Tclin	229.051
solute carrier family 26 member 4	ENSG00000091137	SLC26A4	chr7:107660635-107717809:+	Tbio	424.202
oxytocin receptor	ENSG00000180914	OXTR	chr3:8750408-8769628:-	Tclin	531.432
semaphorin 3A	ENSG00000075213	SEMA3A	chr7:83955777-84492724:-	Tbio	210.598
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	ENSG00000105851	PIK3CG	chr7:106865278-106907145:+	Tchem	182.593
carbonic anhydrase 4	ENSG00000167434	CA4	chr17:60149936-60170899:+	Tclin	420.598
dipeptidyl peptidase 4	ENSG00000197635	DPP4	chr2:161992241-162074542:-	Tclin	2858.74
S100 calcium binding protein B	ENSG00000160307	S100B	chr21:46598962-46605208:-	Tchem	5346.13

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