PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
integrin subunit alpha MENSG00000169896ITGAMchr16:31259990-31332892:+Tbio2004.71
ATPase copper transporting alphaENSG00000165240ATP7AchrX:77910656-78050395:+Tbio346.287
sphingosine-1-phosphate receptor 1ENSG00000170989S1PR1chr1:101236888-101241518:+Tclin289.216
potassium inwardly rectifying channel subfamily J member 11ENSG00000187486KCNJ11chr11:17385859-17389331:-Tclin774.132
granzyme AENSG00000145649GZMAchr5:55102648-55110252:+Tbio170.976
protein kinase cAMP-activated catalytic subunit alphaENSG00000072062PRKACAchr19:14091688-14118084:-Tchem163.772
netrin 1ENSG00000065320NTN1chr17:9021542-9244000:+Tbio208.64
angiotensin I converting enzyme 2ENSG00000130234ACE2chrX:15561033-15602148:-Tchem481.556
caspase 9ENSG00000132906CASP9chr1:15490832-15526534:-Tchem1651.83
neuropilin 1ENSG00000099250NRP1chr10:33177492-33336262:-Tbio453.323
glutamate-ammonia ligaseENSG00000135821GLULchr1:182381704-182392206:-Tchem511.547
glutathione synthetaseENSG00000100983GSSchr20:34928430-34955817:-Tbio238.165
nitric oxide synthase 3ENSG00000164867NOS3chr7:150990995-151014588:+Tchem3944.03
cathepsin EENSG00000196188CTSEchr1:206009264-206023909:-Tchem150.596
hyaluronan synthase 3ENSG00000103044HAS3chr16:69105564-69118719:+Tbio137.768
ectonucleotide pyrophosphatase/phosphodiesterase 2ENSG00000136960ENPP2chr8:119557086-119673453:-Tchem379.045
fibroblast growth factor 1ENSG00000113578FGF1chr5:142592178-142698070:-Tchem745.925
sulfotransferase family 1A member 1ENSG00000196502SULT1A1chr16:28605196-28623625:-Tbio679.363
iodothyronine deiodinase 2ENSG00000211448DIO2chr14:80197527-80387757:-Tbio193.256
secreted frizzled related protein 1ENSG00000104332SFRP1chr8:41261958-41309497:-Tchem316.935

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