PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
protein disulfide isomerase family A member 2ENSG00000185615PDIA2chr16:283152-287215:+Tbio376.74
tachykinin precursor 1ENSG00000006128TAC1chr7:97731908-97740472:+Tbio4666.89
potassium voltage-gated channel subfamily Q member 1ENSG00000053918KCNQ1chr11:2444684-2849109:+Tclin891.018
solute carrier family 3 member 2ENSG00000168003SLC3A2chr11:62856102-62888875:+Tbio238.378
cholinergic receptor nicotinic beta 4 subunitENSG00000117971CHRNB4chr15:78624119-78727754:-Tclin37.427
melanotransferrinENSG00000163975MFI2chr3:196988621-197029816:-Tbio266.99
protein tyrosine phosphatase receptor type Z1ENSG00000106278PTPRZ1chr7:121873089-122062036:+Tbio86.5931
steroid 5 alpha-reductase 1ENSG00000145545SRD5A1chr5:6633343-6674386:+Tclin1570.7
Thy-1 cell surface antigenENSG00000154096THY1chr11:119417378-119424985:-Tbio998.795
cyclin dependent kinase 11AENSG00000008128CDK11Achr1:1702730-1724324:-Tchem25.454
prominin 1ENSG00000007062PROM1chr4:15963076-16084378:-Tbio1503.13
vasoactive intestinal peptide receptor 1ENSG00000114812VIPR1chr3:42489299-42537573:+Tchem316.134
protein tyrosine phosphatase non-receptor type 1ENSG00000196396PTPN1chr20:50510321-50585241:+Tchem863.555
transmembrane protein with EGF like and two follistatin like domains 2ENSG00000144339TMEFF2chr2:191949043-192195709:-Tbio169.758
bone gamma-carboxyglutamate proteinENSG00000242252BGLAPchr1:156241962-156243321:+Tbio662.744
RIO kinase 1ENSG00000124784RIOK1chr6:7389496-7418037:+Tchem4.31667
delta like canonical Notch ligand 4ENSG00000128917DLL4chr15:40929340-40939072:+Tbio250.951
leucyl-tRNA synthetase 1ENSG00000133706LARSchr5:146113038-146182660:-Tchem82.3333
adenosine A1 receptorENSG00000163485ADORA1chr1:203090654-203167405:+Tclin205.93
aquaporin 3 (Gill blood group)ENSG00000165272AQP3chr9:33441154-33447611:-Tbio202.132

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