PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
malic enzyme 1ENSG00000065833ME1chr6:83210389-83431071:-Tchem819.567
cyclin HENSG00000134480CCNHchr5:87391494-87413019:-Tbio78.5313
TNF receptor superfamily member 10dENSG00000173530TNFRSF10Dchr8:23135588-23164030:-Tbio74.4331
carboxylesterase 1ENSG00000198848CES1chr16:55802851-55833337:-Tchem500.069
mutL homolog 1ENSG00000076242MLH1chr3:36993332-37050918:+Tbio1976.31
cathelicidin antimicrobial peptideENSG00000164047CAMPchr3:48223347-48225491:+Tbio1544.58
macrophage scavenger receptor 1ENSG00000038945MSR1chr8:16107878-16567490:-Tbio211.319
oxidized low density lipoprotein receptor 1ENSG00000173391OLR1chr12:10158301-10172138:-Tbio509.377
interleukin 4 induced 1ENSG00000104951IL4I1chr19:49889654-49929539:-Tbio881.663
potassium inwardly rectifying channel subfamily J member 8ENSG00000121361KCNJ8chr12:21764955-21775581:-Tbio107.482
somatostatin receptor 2ENSG00000180616SSTR2chr17:73165012-73176633:+Tclin316.739
colony stimulating factor 2 receptor subunit alphaENSG00000198223CSF2RAchrX:1268800-1310381:+Tclin147.68
ubiquitin specific peptidase 5ENSG00000111667USP5chr12:6852128-6866632:+Tbio36.7324
CD86 moleculeENSG00000114013CD86chr3:122055366-122121139:+Tclin1112.42
aldehyde dehydrogenase 2 family memberENSG00000111275ALDH2chr12:111766887-111817529:+Tclin980.425
collagen type IV alpha 1 chainENSG00000187498COL4A1chr13:110148963-110307149:-Tbio146.08
proteasome 20S subunit alpha 6ENSG00000100902PSMA6chr14:35278633-35317493:+Tbio40.6732
carboxypeptidase EENSG00000109472CPEchr4:165361194-165498320:+Tbio223.789
inhibin subunit beta AENSG00000122641INHBAchr7:41685114-41703108:-Tbio157.604
receptor interacting serine/threonine kinase 2ENSG00000104312RIPK2chr8:89757747-89791063:+Tchem220.614

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