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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
protein tyrosine kinase 2 beta	ENSG00000120899	PTK2B	chr8:27311482-27459391:+	Tchem	792.31
versican	ENSG00000038427	VCAN	chr5:83471465-83582303:+	Tbio	281.963
neurotrophic receptor tyrosine kinase 3	ENSG00000140538	NTRK3	chr15:87859751-88256768:-	Tchem	230.254
PTEN induced kinase 1	ENSG00000158828	PINK1	chr1:20633455-20651511:+	Tbio	576.285
isoleucyl-tRNA synthetase 1	ENSG00000196305	IARS	chr9:92210207-92293756:-	Tchem	609.656
CD81 molecule	ENSG00000110651	CD81	chr11:2376177-2397419:+	Tchem	407.548
apolipoprotein D	ENSG00000189058	APOD	chr3:195568702-195584205:-	Tbio	221.065
collagen type VI alpha 3 chain	ENSG00000163359	COL6A3	chr2:237324003-237414375:-	Tbio	51.8247
arachidonate 5-lipoxygenase activating protein	ENSG00000132965	ALOX5AP	chr13:30713478-30764426:+	Tchem	1440.59
integrin linked kinase	ENSG00000166333	ILK	chr11:6603708-6610874:+	Tchem	387.196
C-X-C motif chemokine receptor 6	ENSG00000172215	CXCR6	chr3:45940933-45948353:+	Tbio	367.644
thyroid peroxidase	ENSG00000115705	TPO	chr2:1374223-1543711:+	Tclin	1403.79
pro-platelet basic protein	ENSG00000163736	PPBP	chr4:73987038-73988197:-	Tbio	1284.31
double PHD fingers 1	ENSG00000011332	DPF1	chr19:38211006-38229714:-	Tbio	6.025
CD99 molecule (Xg blood group)	ENSG00000002586	CD99	chrX:2691179-2741309:+	Tbio	709.307
C-X-C motif chemokine ligand 13	ENSG00000156234	CXCL13	chr4:77511753-77611834:+	Tbio	281.711
ectodysplasin A	ENSG00000158813	EDA	chrX:69616067-70039469:+	Tbio	1162.38
nuclear receptor subfamily 1 group H member 3	ENSG00000025434	NR1H3	chr11:47248300-47269032:+	Tchem	299.791
tubulin beta 4B class IVb	ENSG00000188229	TUBB4B	chr9:137241213-137243707:+	Tclin	147.427
interleukin 1 receptor like 1	ENSG00000115602	IL1RL1	chr2:102311502-102352037:+	Tbio	1427.4

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