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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
bromodomain containing 9	ENSG00000028310	BRD9	chr5:850291-892824:-	Tchem	5.86998
lymphotoxin alpha	ENSG00000226979	LTA	chr6:31572054-31574324:+	Tbio	752.909
retinoic acid receptor alpha	ENSG00000131759	RARA	chr17:40309192-40357643:+	Tclin	1059.89
solute carrier family 16 member 1	ENSG00000155380	SLC16A1	chr1:112911847-112957013:-	Tchem	285.181
reversion inducing cysteine rich protein with kazal motifs	ENSG00000122707	RECK	chr9:36036433-36124451:+	Tbio	176.991
chromogranin B	ENSG00000089199	CHGB	chr20:5911430-5925361:+	Tbio	141
S100 calcium binding protein A9	ENSG00000163220	S100A9	chr1:153357854-153361027:+	Tbio	599.275
heat shock protein family B (small) member 1	ENSG00000106211	HSPB1	chr7:76302544-76304295:+	Tchem	1299.22
phospholipase A2 group IVA	ENSG00000116711	PLA2G4A	chr1:186828953-186988981:+	Tchem	587.544
TNF receptor superfamily member 12A	ENSG00000006327	TNFRSF12A	chr16:3018445-3022383:+	Tbio	108.319
CD40 molecule	ENSG00000101017	CD40	chr20:46118272-46129863:+	Tchem	2382.54
lysine methyltransferase 2A	ENSG00000118058	KMT2A	chr11:118436490-118526832:+	Tchem	1333.41
gigaxonin	ENSG00000261609	GAN	chr16:81314952-81390884:+	Tbio	132.361
ornithine carbamoyltransferase	ENSG00000036473	OTC	chrX:38352545-38421450:+	Tchem	938.978
CD8a molecule	ENSG00000153563	CD8A	chr2:86784610-86808396:-	Tbio	14931
protein kinase C epsilon	ENSG00000171132	PRKCE	chr2:45651345-46187990:+	Tchem	387.912
killer cell lectin like receptor C2	ENSG00000205809	KLRC2	chr12:10426854-10442300:-	Tbio	19.3333
brain derived neurotrophic factor	ENSG00000176697	BDNF	chr11:27654893-27722058:-	Tbio	5694.87
5'-nucleotidase ecto	ENSG00000135318	NT5E	chr6:85449584-85495791:+	Tchem	546.462
CD1e molecule	ENSG00000158488	CD1E	chr1:158353696-158357553:+	Tbio	169.95

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