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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
amyloid beta precursor protein	ENSG00000142192	APP	chr21:25880550-26171128:-	Tchem	9905.46
bone morphogenetic protein receptor type 1B	ENSG00000138696	BMPR1B	chr4:94757968-95158448:+	Tchem	61.3901
Wnt family member 5A	ENSG00000114251	WNT5A	chr3:55465715-55490539:-	Tbio	418.475
laminin subunit alpha 2	ENSG00000196569	LAMA2	chr6:128883141-129516569:+	Tbio	254.232
ceruloplasmin	ENSG00000047457	CP	chr3:149162410-149222055:-	Tbio	334.171
dopachrome tautomerase	ENSG00000080166	DCT	chr13:94436808-94479682:-	Tbio	160.586
histone deacetylase 2	ENSG00000196591	HDAC2	chr6:113933028-114011308:-	Tclin	373.799
ATP binding cassette subfamily G member 1	ENSG00000160179	ABCG1	chr21:42199689-42297244:+	Tbio	206.661
basigin (Ok blood group)	ENSG00000172270	BSG	chr19:571277-583493:+	Tbio	661.532
histone deacetylase 1	ENSG00000116478	HDAC1	chr1:32292086-32333635:+	Tclin	741.688
glucokinase	ENSG00000106633	GCK	chr7:44144271-44198170:-	Tchem	1037.16
somatostatin	ENSG00000157005	SST	chr3:187668906-187670399:-	Tbio	1988.02
transforming growth factor alpha	ENSG00000163235	TGFA	chr2:70447280-70554193:-	Tbio	1055.75
discoidin domain receptor tyrosine kinase 2	ENSG00000162733	DDR2	chr1:162631373-162787400:+	Tchem	106.457
aldo-keto reductase family 1 member C1	ENSG00000187134	AKR1C1	chr10:4963253-5107522:+	Tchem	216.218
ectonucleotide pyrophosphatase/phosphodiesterase 3	ENSG00000154269	ENPP3	chr6:131628442-131747418:+	Tbio	301.418
angiotensin II receptor type 1	ENSG00000144891	AGTR1	chr3:148697784-148743008:+	Tclin	4039.02
pleiotrophin	ENSG00000105894	PTN	chr7:137227341-137343865:-	Tbio	367.612
nuclear receptor subfamily 0 group B member 1	ENSG00000169297	NR0B1	chrX:30304206-30309598:-	Tbio	361.681
somatostatin receptor 5	ENSG00000162009	SSTR5	chr16:1078781-1080142:+	Tclin	179.288

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