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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
cytochrome P450 family 26 subfamily A member 1	ENSG00000095596	CYP26A1	chr10:93073475-93077890:+	Tchem	156.142
nicotinamide N-methyltransferase	ENSG00000166741	NNMT	chr11:114257787-114313285:+	Tchem	99.6543
leucine rich repeat containing G protein-coupled receptor 4	ENSG00000205213	LGR4	chr11:27365961-27472775:-	Tbio	32.9513
brevican	ENSG00000132692	BCAN	chr1:156641390-156659532:+	Tbio	22.9465
lipopolysaccharide binding protein	ENSG00000129988	LBP	chr20:38346356-38377023:+	Tbio	789.046
annexin A2	ENSG00000182718	ANXA2	chr15:60347134-60402883:-	Tbio	828.69
teratocarcinoma-derived growth factor 1	ENSG00000241186	TDGF1	chr3:46574555-46626543:+	Tbio	75.142
C-C motif chemokine ligand 25	ENSG00000131142	CCL25	chr19:8052767-8062650:+	Tbio	68.6793
transforming growth factor beta 3	ENSG00000119699	TGFB3	chr14:75958099-75982991:-	Tbio	575.526
ATPase H+ transporting accessory protein 2	ENSG00000182220	ATP6AP2	chrX:40580908-40606637:+	Tbio	104.798
electron transfer flavoprotein subunit beta lysine methyltransferase	ENSG00000139160	METTL20	chr12:31647160-31673114:+	Tbio	1.83333
ryanodine receptor 1	ENSG00000196218	RYR1	chr19:38433699-38587564:+	Tclin	1013.49
mitogen-activated protein kinase kinase kinase 8	ENSG00000107968	MAP3K8	chr10:30433937-30461833:+	Tchem	102.804
AT-rich interaction domain 4A	ENSG00000032219	ARID4A	chr14:58298385-58373887:+	Tbio	12.7293
ADAM metallopeptidase domain 33	ENSG00000149451	ADAM33	chr20:3667965-3682246:-	Tchem	198.308
serine peptidase inhibitor Kazal type 1	ENSG00000164266	SPINK1	chr5:147824568-147831786:-	Tbio	1251.55
granzyme B	ENSG00000100453	GZMB	chr14:24630954-24634267:-	Tchem	973.629
progastricsin	ENSG00000096088	PGC	chr6:41736711-41754109:-	Tchem	320.951
synaptosome associated protein 25	ENSG00000132639	SNAP25	chr20:10218830-10307418:+	Tbio	621.295
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	ENSG00000244038	DDOST	chr1:20651767-20661544:-	Tchem	200.205

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