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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
hepcidin antimicrobial peptide	ENSG00000105697	HAMP	chr19:35280716-35285143:+	Tbio	313.334
C-X-C motif chemokine ligand 11	ENSG00000169248	CXCL11	chr4:76033682-76041415:-	Tbio	334.513
colony stimulating factor 3 receptor	ENSG00000119535	CSF3R	chr1:36466043-36483278:-	Tclin	253.432
SMG1 nonsense mediated mRNA decay associated PI3K related kinase	ENSG00000157106	SMG1	chr16:18804853-18926454:-	Tchem	1002.66
potassium inwardly rectifying channel subfamily J member 5	ENSG00000120457	KCNJ5	chr11:128891356-128921035:+	Tbio	155.338
C-X-C motif chemokine receptor 2	ENSG00000180871	CXCR2	chr2:218125289-218137253:+	Tchem	462.487
platelet factor 4	ENSG00000163737	PF4	chr4:73981077-73982124:-	Tbio	1161.14
major histocompatibility complex, class I, C	ENSG00000204525	HLA-C	chr6:31268749-31357158:-	Tbio	146.729
premelanosome protein	ENSG00000185664	PMEL	chr12:55954105-55973317:-	Tbio	388.388
hypoxia inducible factor 1 subunit alpha	ENSG00000100644	HIF1A	chr14:61695513-61748259:+	Tchem	5115.75
cytochrome P450 family 2 subfamily C member 8	ENSG00000138115	CYP2C8	chr10:95036772-95069497:-	Tbio	396.654
proenkephalin	ENSG00000181195	PENK	chr8:56436674-56446734:-	Tbio	304.342
neuromedin U	ENSG00000109255	NMU	chr4:55595229-55636698:-	Tbio	76.0808
plasminogen	ENSG00000122194	PLG	chr6:160702238-160753315:+	Tclin	3409.46
aryl hydrocarbon receptor nuclear translocator	ENSG00000143437	ARNT	chr1:150809705-150876768:-	Tbio	314.419
aldo-keto reductase family 1 member C3	ENSG00000196139	AKR1C3	chr10:5035354-5107686:+	Tchem	357.451
tryptophan 2,3-dioxygenase	ENSG00000151790	TDO2	chr4:155854738-155920406:+	Tchem	301.754
BPI fold containing family A member 1	ENSG00000198183	BPIFA1	chr20:33235995-33243311:+	Tbio	122.417
vascular endothelial growth factor D	ENSG00000165197	FIGF	chrX:15345591-15384376:-	Tbio	215.704
CD1d molecule	ENSG00000158473	CD1D	chr1:158179947-158184896:+	Tbio	662.408

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