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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
MALT1 paracaspase	ENSG00000172175	MALT1	chr18:58671386-58754477:+	Tchem	234.254
transforming growth factor beta induced	ENSG00000120708	TGFBI	chr5:136028895-136063818:+	Tbio	531.141
oncostatin M	ENSG00000099985	OSM	chr22:30262829-30266840:-	Tbio	379.235
SET domain bifurcated histone lysine methyltransferase 1	ENSG00000143379	SETDB1	chr1:150926263-150964744:+	Tbio	66.1553
BRCA1 associated protein 1	ENSG00000163930	BAP1	chr3:52401013-52410350:-	Tbio	226.092
cytochrome P450 family 3 subfamily A member 5	ENSG00000106258	CYP3A5	chr7:99648194-99679998:-	Tclin	894.157
high mobility group box 1	ENSG00000189403	HMGB1	chr13:30456704-30617597:-	Tbio	1525.51
MIA SH3 domain containing	ENSG00000261857	MIA	chr19:40771648-40777490:+	Tbio	114.308
decorin	ENSG00000011465	DCN	chr12:91140484-91183123:-	Tbio	431.624
sulfatase 1	ENSG00000137573	SULF1	chr8:69466624-69660915:+	Tbio	86.7385
CD28 molecule	ENSG00000178562	CD28	chr2:203706475-203738912:+	Tbio	1843.49
dystrophin	ENSG00000198947	DMD	chrX:31097677-33339441:-	Tbio	2874.81
complement C7	ENSG00000112936	C7	chr5:40909252-40982939:+	Tbio	450.406
selectin E	ENSG00000007908	SELE	chr1:169722641-169764705:-	Tchem	2239.76
erythropoietin receptor	ENSG00000187266	EPOR	chr19:11377205-11384342:-	Tclin	460.694
solute carrier family 39 member 4	ENSG00000147804	SLC39A4	chr8:144409742-144416895:-	Tbio	81.7199
notch receptor 2	ENSG00000134250	NOTCH2	chr1:119911553-120069626:-	Tchem	221.377
protein tyrosine phosphatase receptor type D	ENSG00000153707	PTPRD	chr9:8314246-10612723:-	Tbio	78.4252
ATP binding cassette subfamily D member 1	ENSG00000101986	ABCD1	chrX:153724868-153744762:+	Tbio	267.771
component of inhibitor of nuclear factor kappa B kinase complex	ENSG00000213341	CHUK	chr10:100188298-100229619:-	Tchem	321.534

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