PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
glutathione peroxidase 4ENSG00000167468GPX4chr19:1103926-1106791:+Tbio199.131
interleukin 1 betaENSG00000125538IL1Bchr2:112829751-112836903:-Tclin11110.5
serum amyloid A1ENSG00000173432SAA1chr11:18266174-18269977:+Tbio406.403
aquaporin 7ENSG00000165269AQP7chr9:33383179-33402682:-Tbio61.0503
TNF superfamily member 13ENSG00000161955TNFSF13chr17:7558292-7561608:+Tbio369.655
hydroxysteroid 11-beta dehydrogenase 1ENSG00000117594HSD11B1chr1:209686178-209734950:+Tclin309.874
adrenoceptor beta 1ENSG00000043591ADRB1chr10:114044056-114046908:+Tclin921.499
CD83 moleculeENSG00000112149CD83chr6:14117256-14136918:+Tbio475.905
retinol binding protein 4ENSG00000138207RBP4chr10:93591687-93601744:-Tchem1314.11
clusterinENSG00000120885CLUchr8:27596917-27615031:-Tbio889.273
sonic hedgehog signaling moleculeENSG00000164690SHHchr7:155799986-155812273:-Tchem1051.53
programmed cell death 4ENSG00000150593PDCD4chr10:110871795-110900006:+Tchem271.045
adenylate cyclase activating polypeptide 1ENSG00000141433ADCYAP1chr18:904943-912172:+Tbio550.7
colony stimulating factor 2 receptor subunit betaENSG00000100368CSF2RBchr22:36913628-36940449:+Tclin123.981
histocompatibility minor 13ENSG00000101294HM13chr20:31514428-31577923:+Tbio405.675
galactosidase alphaENSG00000102393GLAchrX:101397803-101407925:-Tclin1340.17
dual specificity phosphatase 5ENSG00000138166DUSP5chr10:110497838-110511544:+Tbio34.6398
interleukin 21 receptorENSG00000103522IL21Rchr16:27402162-27452042:+Tbio64.4449
carboxyl ester lipaseENSG00000170835CELchr9:133061978-133087355:+Tchem542.209
toll like receptor 2ENSG00000137462TLR2chr4:153701500-153705699:+Tchem1673.94

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