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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
scavenger receptor class B member 1	ENSG00000073060	SCARB1	chr12:124776856-124882668:-	Tchem	533.874
angiotensin I converting enzyme	ENSG00000159640	ACE	chr17:63477061-63498380:+	Tclin	16082.8
cytochrome P450 family 1 subfamily B member 1	ENSG00000138061	CYP1B1	chr2:38066973-38109902:-	Tchem	1160.42
protein tyrosine phosphatase receptor type N	ENSG00000054356	PTPRN	chr2:219289623-219309648:-	Tbio	600.246
TNF superfamily member 4	ENSG00000117586	TNFSF4	chr1:173183734-173207313:-	Tbio	183.906
ubiquitin specific peptidase 39	ENSG00000168883	USP39	chr2:85602856-85649282:+	Tbio	18.8111
histone H3 associated protein kinase	ENSG00000177602	GSG2	chr17:3723903-3726699:+	Tbio	33.7778
ATP binding cassette subfamily C member 2	ENSG00000023839	ABCC2	chr10:99782732-99852192:+	Tbio	763.43
natriuretic peptide receptor 1	ENSG00000169418	NPR1	chr1:153678637-153693992:+	Tclin	185.479
transient receptor potential cation channel subfamily M member 2	ENSG00000142185	TRPM2	chr21:44350163-44443081:+	Tchem	191.147
transforming growth factor beta receptor 2	ENSG00000163513	TGFBR2	chr3:30606502-30694142:+	Tchem	615.962
protein kinase AMP-activated catalytic subunit alpha 1	ENSG00000132356	PRKAA1	chr5:40759379-40798374:-	Tchem	379.504
calcium/calmodulin dependent protein kinase IV	ENSG00000152495	CAMK4	chr5:111223653-111494886:+	Tbio	120.021
glutathione S-transferase mu 1	ENSG00000134184	GSTM1	chr1:109687814-109709039:+	Tbio	2114.63
colony stimulating factor 3	ENSG00000108342	CSF3	chr17:40015361-40017813:+	Tbio	7950.54
programmed cell death 1	ENSG00000188389	PDCD1	chr2:241849881-241858908:-	Tclin	920.798
alanyl aminopeptidase, membrane	ENSG00000166825	ANPEP	chr15:89784889-89815401:-	Tchem	1147.14
carbonic anhydrase 3	ENSG00000164879	CA3	chr8:85373436-85449040:+	Tclin	1382.66
tissue factor pathway inhibitor	ENSG00000003436	TFPI	chr2:187464230-187565760:-	Tbio	1091.74
resistin	ENSG00000104918	RETN	chr19:7669044-7670454:+	Tbio	713.92

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