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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
DNA methyltransferase 3 beta	ENSG00000088305	DNMT3B	chr20:32762385-32809356:+	Tchem	460.366
glucose-6-phosphate isomerase	ENSG00000105220	GPI	chr19:34359480-34402156:+	Tbio	1444.08
vitamin D receptor	ENSG00000111424	VDR	chr12:47841537-47943048:-	Tclin	4357.85
heat shock protein 90 alpha family class A member 1	ENSG00000080824	HSP90AA1	chr14:102080738-102139699:-	Tchem	2607.81
thyroid stimulating hormone receptor	ENSG00000165409	TSHR	chr14:80954989-81146302:+	Tclin	1666.74
C-C motif chemokine ligand 22	ENSG00000102962	CCL22	chr16:57358772-57366190:+	Tbio	268.41
GC vitamin D binding protein	ENSG00000145321	GC	chr4:71741693-71804041:-	Tchem	666.289
proteasome 20S subunit alpha 7	ENSG00000101182	PSMA7	chr20:62136735-62143440:-	Tbio	67.7674
neuropeptide Y	ENSG00000122585	NPY	chr7:24284163-24291865:+	Tbio	1859.09
AKT serine/threonine kinase 3	ENSG00000117020	AKT3	chr1:243488233-243851079:-	Tchem	111.025
complement C3	ENSG00000125730	C3	chr19:6677704-6730562:-	Tbio	4193.13
growth arrest specific 6	ENSG00000183087	GAS6	chr13:113820549-113864067:-	Tbio	235.856
C-X-C motif chemokine ligand 5	ENSG00000163735	CXCL5	chr4:73995642-73998779:-	Tbio	188.675
CD27 molecule	ENSG00000139193	CD27	chr12:6444867-6451718:+	Tbio	587.604
EGF containing fibulin extracellular matrix protein 1	ENSG00000115380	EFEMP1	chr2:55865967-55924139:-	Tbio	121.772
glycogen phosphorylase, muscle associated	ENSG00000068976	PYGM	chr11:64746389-64760297:-	Tchem	299.981
ADAM metallopeptidase with thrombospondin type 1 motif 1	ENSG00000154734	ADAMTS1	chr21:26835747-26845409:-	Tchem	212.697
tenascin C	ENSG00000041982	TNC	chr9:115019578-115118257:-	Tbio	998.146
complement C5	ENSG00000106804	C5	chr9:120952335-121050276:-	Tclin	938.832
integrin subunit alpha 3	ENSG00000005884	ITGA3	chr17:50055968-50090481:+	Tbio	101.138

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