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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
folate receptor alpha	ENSG00000110195	FOLR1	chr11:72189558-72196301:+	Tchem	194.627
prolyl 4-hydroxylase subunit beta	ENSG00000185624	P4HB	chr17:81843159-81860694:-	Tbio	305.65
fibroblast growth factor 9	ENSG00000102678	FGF9	chr13:21671383-21704498:+	Tbio	389.715
CUB domain containing protein 1	ENSG00000163814	CDCP1	chr3:45082278-45146422:-	Tbio	89.2363
NADPH oxidase 4	ENSG00000086991	NOX4	chr11:89324356-89498187:-	Tchem	374.263
serpin family B member 3	ENSG00000057149	SERPINB3	chr18:63637719-63661963:-	Tbio	1826.61
peroxisome proliferator activated receptor alpha	ENSG00000186951	PPARA	chr22:46150521-46243756:+	Tclin	2697.1
erythropoietin	ENSG00000130427	EPO	chr7:100720800-100723700:+	Tbio	14631.2
mesoderm specific transcript	ENSG00000106484	MEST	chr7:130486171-130506296:+	Tbio	151.871
CD244 molecule	ENSG00000122223	CD244	chr1:160830160-160862855:-	Tbio	209.732
cysteine rich secretory protein LCCL domain containing 2	ENSG00000103196	CRISPLD2	chr16:84819984-84920768:+	Tbio	249.89
RAN binding protein 2	ENSG00000153201	RANBP2	chr2:108719481-108785811:+	Tbio	143.779
hypoxanthine phosphoribosyltransferase 1	ENSG00000165704	HPRT1	chrX:134460153-134520513:+	Tchem	1925.72
secreted frizzled related protein 2	ENSG00000145423	SFRP2	chr4:153780592-153789120:-	Tbio	111.841
TNF receptor superfamily member 9	ENSG00000049249	TNFRSF9	chr1:7915894-7943165:-	Tbio	227.634
macrophage migration inhibitory factor	ENSG00000240972	MIF	chr22:23894004-23895227:+	Tchem	1696.24
kallikrein related peptidase 2	ENSG00000167751	KLK2	chr19:50861568-50880567:+	Tchem	151.315
aryl hydrocarbon receptor	ENSG00000106546	AHR	chr7:17298622-17346152:+	Tchem	2095.45
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	ENSG00000174437	ATP2A2	chr12:110280756-110351093:+	Tbio	355.036
C-X3-C motif chemokine receptor 1	ENSG00000168329	CX3CR1	chr3:39263494-39281735:-	Tchem	402.047

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