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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
serpin family E member 1	ENSG00000106366	SERPINE1	chr7:101127089-101139266:+	Tchem	4971.82
solute carrier family 7 member 1	ENSG00000139514	SLC7A1	chr13:29509410-29595688:-	Tbio	478.27
alcohol dehydrogenase 1C (class I), gamma polypeptide	ENSG00000248144	ADH1C	chr4:99336492-99353027:-	Tclin	227.934
integrin subunit alpha 4	ENSG00000115232	ITGA4	chr2:181457202-181536187:+	Tclin	238.716
cathepsin K	ENSG00000143387	CTSK	chr1:150796208-150808323:-	Tchem	658.884
aldolase, fructose-bisphosphate A	ENSG00000149925	ALDOA	chr16:30053090-30070457:+	Tbio	42.9143
ASH2 like, histone lysine methyltransferase complex subunit	ENSG00000129691	ASH2L	chr8:38105242-38144076:+	Tbio	46.8098
nuclear receptor subfamily 3 group C member 2	ENSG00000151623	NR3C2	chr4:148078762-148444698:-	Tclin	287.053
Fc fragment of IgG receptor IIIa	ENSG00000203747	FCGR3A	chr1:161541759-161550737:-	Tbio	2049.36
sialophorin	ENSG00000197471	SPN	chr16:29662979-29670876:+	Tbio	388.617
lipoprotein lipase	ENSG00000175445	LPL	chr8:19901717-19967258:+	Tchem	2480.86
interleukin 4 receptor	ENSG00000077238	IL4R	chr16:27313668-27364778:+	Tclin	527.928
mucin 4, cell surface associated	ENSG00000145113	MUC4	chr3:195746765-195812277:-	Tbio	275.025
CD1b molecule	ENSG00000158485	CD1B	chr1:158327951-158331531:-	Tbio	346.627
major histocompatibility complex, class I, G	ENSG00000204632	HLA-G	chr6:29826967-29831125:+	Tbio	1892.84
CD8b molecule	ENSG00000172116	CD8B	chr2:86815339-86861924:-	Tbio	114.307
bone morphogenetic protein 1	ENSG00000168487	BMP1	chr8:22164736-22212326:+	Tchem	1790.59
TIMP metallopeptidase inhibitor 3	ENSG00000100234	TIMP3	chr22:32801701-32863043:+	Tbio	462.913
spermidine synthase	ENSG00000116649	SRM	chr1:11054584-11060024:-	Tchem	52.7015
prostaglandin E synthase	ENSG00000148344	PTGES	chr9:129738331-129753047:-	Tchem	199.856

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