PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| taste 2 receptor member 7 | ENSG00000121377 | TAS2R7 | chr12:10801532-10802627:- | Tbio | 3.1 |
| olfactory receptor family 1 subfamily S member 2 | ENSG00000197887 | OR1S2 | chr11:58203202-58204181:- | Tdark | 0 |
| olfactory receptor family 5 subfamily AS member 1 | ENSG00000181785 | OR5AS1 | chr11:56030419-56031393:+ | Tdark | 0 |
| olfactory receptor family 4 subfamily F member 15 | ENSG00000182854 | OR4F15 | chr15:101805720-101819147:+ | Tdark | 0.166667 |
| olfactory receptor family 8 subfamily K member 1 | ENSG00000150261 | OR8K1 | chr11:56346039-56346998:+ | Tdark | 0 |
| olfactory receptor family 5 subfamily B member 21 | ENSG00000198283 | OR5B21 | chr11:58507175-58508105:- | Tdark | 0 |
| olfactory receptor family 5 subfamily AN member 1 | ENSG00000176495 | OR5AN1 | chr11:59364412-59365448:+ | Tdark | 1.5 |
| olfactory receptor family 5 subfamily D member 18 | ENSG00000186119 | OR5D18 | chr11:55819630-55820571:+ | Tdark | 0 |
| solute carrier family 22 member 24 | ENSG00000197658 | SLC22A24 | chr11:63079940-63144221:- | Tdark | 1.33333 |
| olfactory receptor family 5 subfamily K member 4 | ENSG00000196098 | OR5K4 | chr3:98353854-98354819:+ | Tdark | 0 |
| olfactory receptor family 13 subfamily D member 1 | ENSG00000179055 | OR13D1 | chr9:104694422-104695462:+ | Tdark | 0 |
| olfactory receptor family 5 subfamily B member 2 | ENSG00000172365 | OR5B2 | chr11:58422265-58423313:- | Tdark | 0 |
| olfactory receptor family 13 subfamily C member 2 | ENSG00000276119 | OR13C2 | chr9:104604671-104605627:- | Tdark | 0 |
| olfactory receptor family 4 subfamily P member 4 | ENSG00000181927 | OR4P4 | chr11:55638358-55639296:+ | Tdark | 0.25 |
| olfactory receptor family 8 subfamily G member 1 | ENSG00000197849 | OR8G1 | chr11:124249676-124250611:+ | Tdark | 0 |
| olfactory receptor family 9 subfamily G member 4 | ENSG00000172457 | OR9G4 | chr11:56742827-56743811:- | Tdark | 0 |
| olfactory receptor family 4 subfamily C member 13 | ENSG00000258817 | OR4C13 | chr11:49952391-49953419:+ | Tdark | 0 |
| olfactory receptor family 6 subfamily C member 68 | ENSG00000205327 | OR6C68 | chr12:55492378-55493316:+ | Tdark | 0 |
| olfactory receptor family 13 subfamily F member 1 | ENSG00000186881 | OR13F1 | chr9:104504263-104505222:+ | Tdark | 9.33333 |
| olfactory receptor family 9 subfamily A member 2 | ENSG00000179468 | OR9A2 | chr7:143026158-143027195:- | Tdark | 0 |
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