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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
Janus kinase 1	ENSG00000162434	JAK1	chr1:64833229-64966504:-	Tclin	368.596
sterol regulatory element binding transcription factor 2	ENSG00000198911	SREBF2	chr22:41833079-41907308:+	Tchem	199.708
selectin L	ENSG00000188404	SELL	chr1:169690667-169711698:-	Tchem	1483.66
thymidine phosphorylase	ENSG00000025708	TYMP	chr22:50525752-50530085:-	Tclin	516.005
transforming growth factor beta 1	ENSG00000105329	TGFB1	chr19:41301587-41353911:-	Tchem	14221.4
ATP binding cassette subfamily C member 6	ENSG00000091262	ABCC6	chr16:16148928-16223522:-	Tbio	267.043
heme oxygenase 1	ENSG00000100292	HMOX1	chr22:35380361-35394214:+	Tbio	2639.88
gamma-glutamyl hydrolase	ENSG00000137563	GGH	chr8:63015079-63039171:-	Tchem	118.07
beta-secretase 2	ENSG00000182240	BACE2	chr21:41167801-41282518:+	Tchem	205.136
prostaglandin E receptor 3	ENSG00000050628	PTGER3	chr1:70852353-71047808:-	Tclin	178.564
aggrecan	ENSG00000157766	ACAN	chr15:88803443-88875354:+	Tbio	150.043
vascular cell adhesion molecule 1	ENSG00000162692	VCAM1	chr1:100719742-100739045:+	Tchem	2196.34
apolipoprotein E	ENSG00000130203	APOE	chr19:44905754-44909393:+	Tbio	12114.2
ATP binding cassette subfamily C member 4	ENSG00000125257	ABCC4	chr13:95019829-95301446:-	Tbio	238.547
C-C motif chemokine receptor 2	ENSG00000121807	CCR2	chr3:46353734-46360928:+	Tchem	668.359
coagulation factor XI	ENSG00000088926	F11	chr4:186265945-186288806:+	Tchem	598.643
pentraxin 3	ENSG00000163661	PTX3	chr3:157436789-157443628:+	Tbio	571.439
ribosomal protein S6 kinase A1	ENSG00000117676	RPS6KA1	chr1:26529761-26575030:+	Tchem	151.904
glypican 3	ENSG00000147257	GPC3	chrX:133535745-133985895:-	Tbio	459.556
ST14 transmembrane serine protease matriptase	ENSG00000149418	ST14	chr11:130159562-130210376:+	Tchem	166.198

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