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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
membrane metalloendopeptidase	ENSG00000196549	MME	chr3:155024124-155183729:+	Tclin	2454.29
solute carrier family 39 member 6	ENSG00000141424	SLC39A6	chr18:36108532-36129385:-	Tbio	50.0922
solute carrier family 2 member 4	ENSG00000181856	SLC2A4	chr17:7281667-7288257:+	Tbio	1100.33
4-aminobutyrate aminotransferase	ENSG00000183044	ABAT	chr16:8674565-8784575:+	Tclin	366.475
CD5 molecule	ENSG00000110448	CD5	chr11:61102395-61127852:+	Tbio	1565.04
mitogen-activated protein kinase kinase 2	ENSG00000126934	MAP2K2	chr19:4090321-4124129:-	Tclin	108.58
C-X-C motif chemokine ligand 1	ENSG00000163739	CXCL1	chr4:73869393-73871242:+	Tbio	419.96
bone morphogenetic protein 6	ENSG00000153162	BMP6	chr6:7726797-7881422:+	Tbio	192.969
transforming growth factor beta 2	ENSG00000092969	TGFB2	chr1:218346235-218444619:+	Tbio	844.204
peptidylprolyl isomerase A	ENSG00000196262	PPIA	chr7:44796680-44824564:+	Tclin	518.555
collagen triple helix repeat containing 1	ENSG00000164932	CTHRC1	chr8:103371515-103382997:+	Tbio	37.3469
collagen type III alpha 1 chain	ENSG00000168542	COL3A1	chr2:188974320-189012746:+	Tbio	310.52
bone morphogenetic protein 7	ENSG00000101144	BMP7	chr20:57168748-57266629:-	Tbio	822.402
placental growth factor	ENSG00000119630	PGF	chr14:74941834-74955784:-	Tclin	1033.87
protein tyrosine phosphatase non-receptor type 22	ENSG00000134242	PTPN22	chr1:113813811-113871759:-	Tchem	1250.26
tumor susceptibility 101	ENSG00000074319	TSG101	chr11:18468336-18527232:-	Tbio	228.807
notch receptor 3	ENSG00000074181	NOTCH3	chr19:15159038-15200981:-	Tchem	721.706
signaling lymphocytic activation molecule family member 1	ENSG00000117090	SLAMF1	chr1:160608100-160647295:-	Tbio	337.759
transformation/transcription domain associated protein	ENSG00000196367	TRRAP	chr7:98877933-99013243:+	Tbio	52.8835
TEK receptor tyrosine kinase	ENSG00000120156	TEK	chr9:27109141-27230175:+	Tclin	636.091

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