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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
general transcription factor IIIC subunit 4	ENSG00000125484	GTF3C4	chr9:132670035-132694955:+	Tdark	0.630556
CD55 molecule (Cromer blood group)	ENSG00000196352	CD55	chr1:207321508-207360966:+	Tbio	767.656
myelin transcription factor 1	ENSG00000196132	MYT1	chr20:64151791-64242253:+	Tchem	37.7767
superoxide dismutase 1	ENSG00000142168	SOD1	chr21:31659622-31668931:+	Tbio	5448.54
hemoglobin subunit beta	ENSG00000244734	HBB	chr11:5225464-5229395:-	Tbio	1063.71
arginyl-tRNA synthetase 1	ENSG00000113643	RARS	chr5:168486445-168519299:+	Tchem	123.38
reelin	ENSG00000189056	RELN	chr7:103471784-103989516:-	Tbio	381.69
glutathione peroxidase 1	ENSG00000233276	GPX1	chr3:49357176-49358600:-	Tbio	442.982
DNA polymerase alpha 1, catalytic subunit	ENSG00000101868	POLA1	chrX:24693919-24996986:+	Tclin	1157.7
erb-b2 receptor tyrosine kinase 4	ENSG00000178568	ERBB4	chr2:211375717-212538841:-	Tclin	488.941
ATP binding cassette subfamily C member 3	ENSG00000108846	ABCC3	chr17:50634777-50692252:+	Tbio	446.745
TNF receptor superfamily member 11a	ENSG00000141655	TNFRSF11A	chr18:62325287-62391292:+	Tbio	172.603
lysine demethylase 4C	ENSG00000107077	KDM4C	chr9:6757641-7175648:+	Tchem	48.7138
solute carrier family 2 member 3	ENSG00000059804	SLC2A3	chr12:7919230-7936275:-	Tchem	205.421
serpin family B member 2	ENSG00000197632	SERPINB2	chr18:63871692-63903890:+	Tbio	388.41
tumor necrosis factor	ENSG00000232810	TNF	chr6:31575567-31578336:+	Tclin	39486.8
major histocompatibility complex, class I, A	ENSG00000206503	HLA-A	chr6:29941260-29945884:+	Tbio	2865.77
alkaline phosphatase, placental	ENSG00000163283	ALPP	chr2:232378534-232382889:+	Tbio	3112.67
baculoviral IAP repeat containing 2	ENSG00000110330	BIRC2	chr11:102347211-102378670:+	Tchem	259.97
NAD(P)H quinone dehydrogenase 1	ENSG00000181019	NQO1	chr16:69706996-69726951:-	Tchem	1307.79

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