PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
dopamine receptor D2ENSG00000149295DRD2chr11:113409615-113475691:-Tclin2726.55
zinc finger MYND-type containing 11ENSG00000015171ZMYND11chr10:134465-254637:+Tbio29.3662
leucine rich repeat kinase 2ENSG00000188906LRRK2chr12:40196744-40369285:+Tchem1294.44
PR/SET domain 1ENSG00000057657PRDM1chr6:106086320-106109939:+Tbio236.216
lysyl oxidase like 2ENSG00000134013LOXL2chr8:23297189-23425328:-Tbio80.3796
WD repeat domain 5ENSG00000196363WDR5chr9:134135365-134159968:+Tchem67.3449
protein kinase C iotaENSG00000163558PRKCIchr3:170222365-170305981:+Tchem85.569
laminin subunit beta 3ENSG00000196878LAMB3chr1:209614870-209652466:-Tbio124.173
Fos proto-oncogene, AP-1 transcription factor subunitENSG00000170345FOSchr14:75278774-75282230:+Tbio3823.55
microtubule associated protein tauENSG00000186868MAPTchr17:45894382-46028334:+Tchem1699.58
survival motor neuron domain containing 1ENSG00000119953SMNDC1chr10:110290730-110304951:-Tbio50.5149
CD52 moleculeENSG00000169442CD52chr1:26317957-26320523:+Tclin487.029
mitogen-activated protein kinase kinase kinase 7ENSG00000135341MAP3K7chr6:90513573-90587045:-Tchem268.414
nuclear receptor subfamily 5 group A member 1ENSG00000136931NR5A1chr9:124481236-124507430:-Tchem465.076
acetylcholinesterase (Cartwright blood group)ENSG00000087085ACHEchr7:100889994-100896974:-Tclin4664.05
interleukin 12AENSG00000168811IL12Achr3:159988750-159996019:+Tclin357.869
interleukin 2 receptor subunit alphaENSG00000134460IL2RAchr10:6010689-6062325:-Tclin3528.96
glucose-6-phosphate dehydrogenaseENSG00000160211G6PDchrX:154531391-154547572:-Tchem6611.62
klothoENSG00000133116KLchr13:33016433-33066145:+Tbio440.31
C-C motif chemokine receptor 5ENSG00000160791CCR5chr3:46370854-46376206:+Tclin2862.53

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