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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
coenzyme Q8B	ENSG00000123815	ADCK4	chr19:40691529-40718207:-	Tchem	2.38333
neuropeptide Y receptor Y5	ENSG00000164129	NPY5R	chr4:163343939-163351934:+	Tchem	89.1087
immunoglobulin kappa variable 1-39	ENSG00000242371	IGKV1-39	chr2:89319625-89320146:-	Tdark	0
immunoglobulin kappa variable 5-2	ENSG00000211599	IGKV5-2	chr2:88897232-88897784:+	Tdark	4.86667
heat shock protein 90 alpha family class A member 2, pseudogene	ENSG00000224411	HSP90AA2P	chr11:27888838-27891033:-	Tbio	6.98809
glycine receptor alpha 1	ENSG00000145888	GLRA1	chr5:151822513-151924842:-	Tclin	139.161
neuropeptide Y receptor Y6 (pseudogene)	ENSG00000226306	NPY6R	chr5:137801193-137810751:+	Tbio	1
aldo-keto reductase family 7 like (gene/pseudogene)	ENSG00000211454	AKR7L	chr1:19265982-19274194:-	Tdark	2.5
YY1 associated factor 2	ENSG00000015153	YAF2	chr12:42157104-42238349:-	Tbio	3.47619
immunoglobulin lambda variable 3-27	ENSG00000211658	IGLV3-27	chr22:22668288-22668806:+	Tdark	0
PR/SET domain 13	ENSG00000112238	PRDM13	chr6:99606730-99615578:+	Tbio	3.80952
ADAM metallopeptidase domain 2	ENSG00000104755	ADAM2	chr8:39743735-39838289:-	Tbio	42.9016
solute carrier family 25 member 47	ENSG00000140107	SLC25A47	chr14:100323337-100330378:+	Tbio	1.83333
immunoglobulin lambda variable 4-60	ENSG00000211639	IGLV4-60	chr22:22162199-22162681:+	Tdark	0.166667
gamma-aminobutyric acid type A receptor subunit beta1	ENSG00000163288	GABRB1	chr4:46993723-47426444:+	Tclin	21.2869
chymotrypsin like elastase 1	ENSG00000139610	CELA1	chr12:51328443-51346679:-	Tchem	213.724
immunoglobulin kappa variable 2-30	ENSG00000243238	IGKV2-30	chr2:89244781-89245596:-	Tdark	0
immunoglobulin lambda variable 1-36	ENSG00000211655	IGLV1-36	chr22:22431958-22432465:+	Tdark	0
immunoglobulin kappa variable 1D-16	ENSG00000241244	IGKV1D-16	chr2:90100236-90100738:+	Tdark	0
angiogenic factor with G-patch and FHA domains 1	ENSG00000164252	AGGF1	chr5:77029251-77065234:+	Tbio	16.0803

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