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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
transient receptor potential cation channel subfamily M member 6	ENSG00000119121	TRPM6	chr9:74722495-74888094:-	Tchem	87.4122
melanocortin 5 receptor	ENSG00000176136	MC5R	chr18:13824155-13826743:+	Tchem	112.769
protein kinase Y-linked (pseudogene)	ENSG00000099725	PRKY	chrY:7273972-7381548:+	Tdark	1.83333
interleukin 5 receptor subunit alpha	ENSG00000091181	IL5RA	chr3:3066326-3126613:-	Tclin	101.415
regenerating family member 3 gamma	ENSG00000143954	REG3G	chr2:79025686-79028505:+	Tbio	4.975
gonadotropin releasing hormone receptor 2 (pseudogene)	ENSG00000211451	GNRHR2	chr1:145919013-145925341:+	Tbio	5.5
olfactory receptor family 1 subfamily L member 8	ENSG00000171496	OR1L8	chr9:122567548-122568477:-	Tdark	0
mucin 2, oligomeric mucus/gel-forming	ENSG00000198788	MUC2	chr11:1074875-1110511:+	Tbio	658.387
gonadotropin releasing hormone 2	ENSG00000125787	GNRH2	chr20:3043622-3045747:+	Tbio	14.5
calcium voltage-gated channel auxiliary subunit gamma 6	ENSG00000130433	CACNG6	chr19:53992288-54012669:+	Tdark	2.28373
usherin	ENSG00000042781	USH2A	chr1:215622894-216423396:-	Tbio	360.951
G protein-coupled receptor 22	ENSG00000172209	GPR22	chr7:107470018-107475659:+	Tdark	3.81667
solute carrier family 25 member 31	ENSG00000151475	SLC25A31	chr4:127730378-127774299:+	Tbio	21.3667
defensin alpha 4	ENSG00000164821	DEFA4	chr8:6935822-6938338:-	Tbio	39.8135
glycoprotein hormone subunit alpha 2	ENSG00000149735	GPHA2	chr11:64934471-64935888:-	Tbio	44.4179
calcitonin receptor	ENSG00000004948	CALCR	chr7:93424487-93574730:-	Tclin	556.889
potassium voltage-gated channel subfamily E regulatory subunit 1	ENSG00000180509	KCNE1	chr21:34446688-34512275:-	Tbio	314.802
C-type lectin domain family 3 member A	ENSG00000166509	CLEC3A	chr16:78022515-78066761:+	Tdark	2.34444
immunoglobulin heavy constant delta	ENSG00000211898	IGHD	chr14:105836765-105845678:-	Tbio	3.78254
hypocretin neuropeptide precursor	ENSG00000161610	HCRT	chr17:42184060-42185452:-	Tbio	127.767

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