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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
melatonin receptor 1A	ENSG00000168412	MTNR1A	chr4:186533655-186555567:-	Tclin	88.4214
tachykinin precursor 4	ENSG00000176358	TAC4	chr17:49838309-49848017:-	Tbio	17.4607
olfactory receptor family 2 subfamily A member 7	ENSG00000243896	OR2A7	chr7:144258607-144259722:-	Tdark	0
cytochrome P450 family 4 subfamily F member 8	ENSG00000186526	CYP4F8	chr19:15615218-15630638:+	Tdark	10.9956
free fatty acid receptor 1	ENSG00000126266	FFAR1	chr19:35351552-35353862:+	Tchem	154.608
solute carrier family 22 member 20, pseudogene	ENSG00000197847	SLC22A20	chr11:65213840-65242757:+	Tdark	0.166667
immunoglobulin heavy constant epsilon	ENSG00000211891	IGHE	chr14:105599941-105601728:-	Tclin	10.0333
collectin subfamily member 10	ENSG00000184374	COLEC10	chr8:118995452-119106582:+	Tbio	24.1929
prodynorphin	ENSG00000101327	PDYN	chr20:1978757-1994285:-	Tbio	567.453
interferon alpha 8	ENSG00000120242	IFNA8	chr9:21409147-21410185:+	Tbio	95.463
transient receptor potential cation channel subfamily V member 5	ENSG00000127412	TRPV5	chr7:142908101-142933808:-	Tbio	102.849
doublecortin like kinase 3	ENSG00000163673	DCLK3	chr3:36712422-36739861:-	Tchem	31.1973
pancreatic lipase related protein 2 (gene/pseudogene)	ENSG00000266200	PNLIPRP2	chr10:116620953-116645143:+	Tbio	33.55
solute carrier family 6 member 7	ENSG00000011083	SLC6A7	chr5:150189957-150222788:+	Tchem	675.145
macrophage stimulating 1 like	ENSG00000186715	MST1L	chr1:16754910-16770237:-	Tdark	0.5
immunoglobulin kappa variable 1D-39	ENSG00000251546	IGKV1D-39	chr2:89862482-89862981:+	Tdark	3
cathepsin L family member 3, pseudogene	ENSG00000188029	CTSL3P	chr9:87772453-87786884:+	Tdark	0
TUB like protein 2	ENSG00000104804	TULP2	chr19:48880965-48898733:-	Tdark	1.00952
mitochondrial carrier 1	ENSG00000137409	MTCH1	chr6:36968141-36986298:-	Tbio	7.49206
chorionic gonadotropin subunit beta 8	ENSG00000213030	CGB8	chr19:49047638-49049106:-	Tdark	5.11667

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