PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
lysophosphatidic acid receptor 4ENSG00000147145LPAR4chrX:78747709-78757094:+Tchem19.0159
butyrophilin subfamily 3 member A3ENSG00000111801BTN3A3chr6:26440472-26453415:+Tdark3.70357
lactamase betaENSG00000103642LACTBchr15:63121800-63142061:+Tbio18.6583
complement C1r subcomponent likeENSG00000139178C1RLchr12:7089587-7109273:-Tbio3.50952
zinc finger CW-type and PWWP domain containing 2ENSG00000206559ZCWPW2chr3:28349146-28538122:+Tdark0.375
tectorin alphaENSG00000109927TECTAchr11:121101173-121191493:+Tbio93.4334
melanocortin 3 receptorENSG00000124089MC3Rchr20:56248732-56249815:+Tchem208.702
retinol dehydrogenase 8ENSG00000080511RDH8chr19:10013249-10022279:+Tbio8.35417
thioredoxin related transmembrane protein 1ENSG00000139921TMX1chr14:51240162-51257546:+Tbio17.9012
neurexophilin and PC-esterase domain family member 1ENSG00000095110NXPE1chr11:114521715-114559895:-Tdark0.791667
statherinENSG00000126549STATHchr4:69995930-70002570:+Tbio248.813
potassium inwardly rectifying channel subfamily J member 6ENSG00000157542KCNJ6chr21:37607376-37916446:-Tbio103.534
adenylate cyclase 10ENSG00000143199ADCY10chr1:167809388-167914215:-Tchem100.805
G protein-coupled receptor 82ENSG00000171657GPR82chrX:41724155-41730135:+Tdark0.512588
solute carrier family 2 member 8ENSG00000136856SLC2A8chr9:127397138-127408424:+Tbio13.6813
sterol O-acyltransferase 2ENSG00000167780SOAT2chr12:53103518-53124538:+Tchem27.0206
contactin associated protein family member 3ENSG00000106714CNTNAP3chr9:39072767-39288315:-Tdark3.55
matrilin 1ENSG00000162510MATN1chr1:30711277-30723587:-Tbio73.1107
growth hormone 2ENSG00000136487GH2chr17:63880215-63881935:-Tbio11.5333
thyrotropin releasing hormone receptorENSG00000174417TRHRchr8:109086621-109119584:+Tclin82.7784

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