PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| lysophosphatidic acid receptor 4 | ENSG00000147145 | LPAR4 | chrX:78747709-78757094:+ | Tchem | 19.0159 |
| butyrophilin subfamily 3 member A3 | ENSG00000111801 | BTN3A3 | chr6:26440472-26453415:+ | Tdark | 3.70357 |
| lactamase beta | ENSG00000103642 | LACTB | chr15:63121800-63142061:+ | Tbio | 18.6583 |
| complement C1r subcomponent like | ENSG00000139178 | C1RL | chr12:7089587-7109273:- | Tbio | 3.50952 |
| zinc finger CW-type and PWWP domain containing 2 | ENSG00000206559 | ZCWPW2 | chr3:28349146-28538122:+ | Tdark | 0.375 |
| tectorin alpha | ENSG00000109927 | TECTA | chr11:121101173-121191493:+ | Tbio | 93.4334 |
| melanocortin 3 receptor | ENSG00000124089 | MC3R | chr20:56248732-56249815:+ | Tchem | 208.702 |
| retinol dehydrogenase 8 | ENSG00000080511 | RDH8 | chr19:10013249-10022279:+ | Tbio | 8.35417 |
| thioredoxin related transmembrane protein 1 | ENSG00000139921 | TMX1 | chr14:51240162-51257546:+ | Tbio | 17.9012 |
| neurexophilin and PC-esterase domain family member 1 | ENSG00000095110 | NXPE1 | chr11:114521715-114559895:- | Tdark | 0.791667 |
| statherin | ENSG00000126549 | STATH | chr4:69995930-70002570:+ | Tbio | 248.813 |
| potassium inwardly rectifying channel subfamily J member 6 | ENSG00000157542 | KCNJ6 | chr21:37607376-37916446:- | Tbio | 103.534 |
| adenylate cyclase 10 | ENSG00000143199 | ADCY10 | chr1:167809388-167914215:- | Tchem | 100.805 |
| G protein-coupled receptor 82 | ENSG00000171657 | GPR82 | chrX:41724155-41730135:+ | Tdark | 0.512588 |
| solute carrier family 2 member 8 | ENSG00000136856 | SLC2A8 | chr9:127397138-127408424:+ | Tbio | 13.6813 |
| sterol O-acyltransferase 2 | ENSG00000167780 | SOAT2 | chr12:53103518-53124538:+ | Tchem | 27.0206 |
| contactin associated protein family member 3 | ENSG00000106714 | CNTNAP3 | chr9:39072767-39288315:- | Tdark | 3.55 |
| matrilin 1 | ENSG00000162510 | MATN1 | chr1:30711277-30723587:- | Tbio | 73.1107 |
| growth hormone 2 | ENSG00000136487 | GH2 | chr17:63880215-63881935:- | Tbio | 11.5333 |
| thyrotropin releasing hormone receptor | ENSG00000174417 | TRHR | chr8:109086621-109119584:+ | Tclin | 82.7784 |
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