PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusionENSG00000166664CHRFAM7Achr15:30357766-30393849:-Tchem11.5
defensin beta 103AENSG00000176797DEFB103Achr8:7881204-7882664:+0
tudor domain containing 7ENSG00000196116TDRD7chr9:97411950-97496125:+Tbio7.46302
ASXL transcriptional regulator 2ENSG00000143970ASXL2chr2:25733753-25878516:-Tbio7.97064
all-trans retinoic acid induced differentiation factorENSG00000138085ATRAIDchr2:27212027-27217178:+Tbio21.1722
solute carrier family 35 member B3ENSG00000124786SLC35B3chr6:8413068-8435483:-Tdark5.80952
G protein-coupled receptor 156ENSG00000175697GPR156chr3:120164645-120285094:-Tbio3
cyclin dependent kinase 17ENSG00000059758CDK17chr12:96278261-96400560:-Tchem1.09546
sulfotransferase family 1A member 3ENSG00000261052SULT1A3chr16:30199228-30204310:+Tbio637.054
glycerol-3-phosphate dehydrogenase 2ENSG00000115159GPD2chr2:156435290-156613735:+Tbio39.8965
PR/SET domain 4ENSG00000110851PRDM4chr12:107732866-107761272:-Tbio8.41667
lysine demethylase 4AENSG00000066135KDM4Achr1:43650158-43705515:+Tchem89.3569
solute carrier family 14 member 2ENSG00000132874SLC14A2chr18:45212995-45683686:+Tbio87.2151
solute carrier family 26 member 8ENSG00000112053SLC26A8chr6:35943514-36024868:-Tbio93.4369
ATPase phospholipid transporting 9A (putative)ENSG00000054793ATP9Achr20:51596514-51768634:-Tdark1.04841
phospholipase C zeta 1ENSG00000139151PLCZ1chr12:18683169-18738057:-Tbio52.475
lipocalin 6ENSG00000267206LCN6chr9:136744011-136748528:-Tbio3.45
propionyl-CoA carboxylase subunit betaENSG00000114054PCCBchr3:136250306-136337896:+Tbio55.915
solute carrier family 5 member 2ENSG00000140675SLC5A2chr16:31483002-31490860:+Tclin586.65
gamma-glutamyltransferase light chain 2ENSG00000100121GGTLC2chr22:22644475-22647903:+Tdark0.166667

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