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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
ATP/GTP binding protein like 5	ENSG00000084693	AGBL5	chr2:27042364-27070622:+	Tbio	4.20833
somatostatin receptor 4	ENSG00000132671	SSTR4	chr20:23035386-23036812:+	Tclin	44.4889
solute carrier family 25 member 51	ENSG00000122696	SLC25A51	chr9:37879400-37904353:-	Tdark	1.04
p21 (RAC1) activated kinase 6	ENSG00000137843	PAK6	chr15:40238759-40277487:+	Tchem	28.5637
solute carrier family 35 member A5	ENSG00000138459	SLC35A5	chr3:112561709-112585577:+	Tdark	0.25
chromosome 6 open reading frame 120	ENSG00000185127	C6orf120	chr6:169702190-169704856:+	Tdark	1.37549
adhesion G protein-coupled receptor F3	ENSG00000173567	ADGRF3	chr2:26308173-26346817:-	Tdark	2.37833
solute carrier family 35 member B4	ENSG00000205060	SLC35B4	chr7:134289332-134317051:-	Tbio	4.71026
carboxypeptidase O	ENSG00000144410	CPO	chr2:206939554-206969474:+	Tdark	8
hypocretin receptor 1	ENSG00000121764	HCRTR1	chr1:31617686-31632518:+	Tclin	70.9686
ecto-NOX disulfide-thiol exchanger 2	ENSG00000165675	ENOX2	chrX:130623369-130903317:-	Tbio	55.6929
retinol binding protein 3	ENSG00000265203	RBP3	chr10:47348371-47357875:+	Tbio	220.024
CDGSH iron sulfur domain 1	ENSG00000122873	CISD1	chr10:58269058-58289586:+	Tchem	55.1857
mortality factor 4 like 1	ENSG00000185787	MORF4L1	chr15:78810487-78898133:+	Tbio	24.519
hydroxysteroid dehydrogenase like 1	ENSG00000103160	HSDL1	chr16:84122146-84145192:-	Tdark	4.11111
dopamine receptor D3	ENSG00000151577	DRD3	chr3:114128652-114199407:-	Tclin	382.09
acid sensing ion channel subunit 2	ENSG00000108684	ASIC2	chr17:33013087-34174964:-	Tbio	67.2198
solute carrier family 25 member 14	ENSG00000102078	SLC25A14	chrX:130339888-130373361:+	Tbio	24.5016
SEC11 homolog A, signal peptidase complex subunit	ENSG00000140612	SEC11A	chr15:84669538-84716716:-	Tbio	5.81905
tryptophan hydroxylase 2	ENSG00000139287	TPH2	chr12:71938846-72186618:+	Tchem	365.479

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