PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
X-prolyl aminopeptidase 3ENSG00000196236XPNPEP3chr22:40857077-40932815:+Tbio20.0755
cytochrome b5 reductase 1ENSG00000159348CYB5R1chr1:202961869-202967280:-Tbio0.034483
phosphoribosyl pyrophosphate synthetase associated protein 1ENSG00000161542PRPSAP1chr17:76309486-76384521:-Tbio9.21111
complement factor H related 5ENSG00000134389CFHR5chr1:196977556-197009674:+Tbio39.6802
complement factor H related 4ENSG00000134365CFHR4chr1:196850241-196918972:+Tbio12.6192
mannosidase alpha class 2C member 1ENSG00000140400MAN2C1chr15:75355207-75368630:-Tbio76.35
lysozyme g2ENSG00000185674LYG2chr2:99242246-99255282:-Tbio3.5
integrin alpha FG-GAP repeat containing 1ENSG00000129636ITFG1chr16:47154387-47464149:-Tbio6.25327
immunoglobulin heavy constant muENSG00000211899IGHMchr14:105854220-106235572:-Tbio0
guanylate cyclase 2D, retinalENSG00000132518GUCY2Dchr17:8002594-8020339:+Tbio165.905
transmembrane p24 trafficking protein 1ENSG00000099203TMED1chr19:10832438-10836318:-Tdark2.08333
solute carrier family 12 member 1ENSG00000074803SLC12A1chr15:48191664-48304078:+Tclin293.887
PHD finger protein 8ENSG00000172943PHF8chrX:53936676-54048958:-Tchem38.313
lipase F, gastric typeENSG00000182333LIPFchr10:88664441-88678814:+Tclin186.759
protein tyrosine phosphatase non-receptor type 18ENSG00000072135PTPN18chr2:130356007-130375409:+Tbio8.64803
leukocyte cell derived chemotaxin 2ENSG00000145826LECT2chr5:135922279-135955034:-Tbio61.0647
calcium voltage-gated channel auxiliary subunit gamma 1ENSG00000108878CACNG1chr17:67044590-67056797:+Tbio8.45397
casein kinase 1 gamma 3ENSG00000151292CSNK1G3chr5:123512099-123617045:+Tbio2.83333
gamma-aminobutyric acid type A receptor subunit gamma1ENSG00000163285GABRG1chr4:46035769-46124081:-Tclin18.6785
megakaryocyte and platelet inhibitory receptor G6bENSG00000204420C6orf25chr6:31718594-31726714:+Tbio32.0944

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