PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
kelch like family member 24ENSG00000114796KLHL24chr3:183635568-183684477:+Tbio3.90952
glucose-fructose oxidoreductase domain containing 2ENSG00000141098GFOD2chr16:67674531-67719421:-Tdark2.0625
solute carrier family 25 member 40ENSG00000075303SLC25A40chr7:87833568-87876357:-Tdark10.7674
proline rich protein HaeIII subfamily 1ENSG00000231887PRH1chr12:10824960-11171544:-0
PHD finger protein 11ENSG00000136147PHF11chr13:49495610-49528987:+Tbio39.71
trypsin like peroxisomal matrix peptidase 1ENSG00000156521TYSND1chr10:70137981-70146676:-Tbio1.5
arylsulfatase family member HENSG00000205667ARSHchrX:3006613-3033571:+Tbio564.712
solute carrier family 12 member 3ENSG00000070915SLC12A3chr16:56865207-56915850:+Tclin285.46
H4 clustered histone 11ENSG00000197238HIST1H4Jchr6:27824108-27824480:+0
TM2 domain containing 1ENSG00000162604TM2D1chr1:61681046-61725423:-Tdark6.16667
pyroglutamylated RFamide peptideENSG00000188710QRFPchr9:130892702-130896812:-Tbio26.45
chromobox 5ENSG00000094916CBX5chr12:54230940-54280133:-Tbio390.764
taste 2 receptor member 4ENSG00000127364TAS2R4chr7:141778442-141780819:+Tbio14.9
taste 2 receptor member 20ENSG00000255837TAS2R20chr12:10996495-10997875:-Tbio0.333333
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1ENSG00000125498KIR2DL1chr19:54769811-54784322:+Tbio116.145
solute carrier family 9 member A8ENSG00000197818SLC9A8chr20:49812713-49892242:+Tbio13.8373
phosphatidylinositol-5-phosphate 4-kinase type 2 gammaENSG00000166908PIP4K2Cchr12:57591174-57603418:+Tchem31.3101
glutamate decarboxylase 2ENSG00000136750GAD2chr10:26216307-26304558:+Tbio676.754
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2ENSG00000136044APPL2chr12:105173296-105236238:-Tbio11.3802
STE20 related adaptor betaENSG00000082146STRADBchr2:201387858-201480846:+Tbio6.46349

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