PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| killer cell lectin like receptor D1 | ENSG00000134539 | KLRD1 | chr12:10226058-10329600:+ | Tbio | 225.519 |
| solute carrier family 22 member 10 | ENSG00000184999 | SLC22A10 | chr11:63137867-63369718:+ | Tdark | 2.58333 |
| acid phosphatase 2, lysosomal | ENSG00000134575 | ACP2 | chr11:47239302-47248906:- | Tbio | 37.9454 |
| growth differentiation factor 7 | ENSG00000143869 | GDF7 | chr2:20666664-20679245:+ | Tbio | 18.8706 |
| growth hormone releasing hormone receptor | ENSG00000106128 | GHRHR | chr7:30938669-30993254:+ | Tclin | 180.062 |
| calcium voltage-gated channel auxiliary subunit gamma 3 | ENSG00000006116 | CACNG3 | chr16:24255553-24362801:+ | Tbio | 4.34722 |
| transmembrane protein 94 | ENSG00000177728 | KIAA0195 | chr17:75441159-75500090:+ | Tdark | 0 |
| SMYD family member 5 | ENSG00000135632 | SMYD5 | chr2:73214222-73227237:+ | Tbio | 2.04167 |
| serine/threonine/tyrosine interacting like 1 | ENSG00000127952 | STYXL1 | chr7:75996338-76048004:- | Tbio | 6.98333 |
| major facilitator superfamily domain containing 14B | ENSG00000148110 | HIATL1 | chr9:94374551-94461042:+ | Tdark | 0.076923 |
| major facilitator superfamily domain containing 14A | ENSG00000156875 | HIAT1 | chr1:100038097-100083377:+ | Tbio | 0.576923 |
| SV2 related protein | ENSG00000166111 | SVOP | chr12:108907741-109021240:- | Tdark | 1.16667 |
| casein kinase 1 gamma 1 | ENSG00000169118 | CSNK1G1 | chr15:64165517-64356187:- | Tbio | 4.85606 |
| UDP glucuronosyltransferase family 2 member B10 | ENSG00000109181 | UGT2B10 | chr4:68815993-68831196:+ | Tbio | 23.8118 |
| potassium voltage-gated channel subfamily H member 3 | ENSG00000135519 | KCNH3 | chr12:49539157-49558308:+ | Tclin | 4.88333 |
| taste 2 receptor member 30 | ENSG00000256188 | TAS2R30 | chr12:11077313-11134644:- | Tbio | 0.9 |
| ameloblastin | ENSG00000178522 | AMBN | chr4:70592256-70607288:+ | Tbio | 100.572 |
| H4 clustered histone 9 | ENSG00000276180 | HIST1H4I | chr6:27138588-27139881:+ | 0 | |
| pyridoxal dependent decarboxylase domain containing 1 | ENSG00000179889 | PDXDC1 | chr16:14974591-15139339:+ | Tdark | 1.20667 |
| EBP like | ENSG00000123179 | EBPL | chr13:49660723-49691475:- | Tchem | 0.958333 |
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