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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
vitelline membrane outer layer 1 homolog	ENSG00000182853	VMO1	chr17:4785285-4786433:-	Tdark	2.7
adenosine A2a receptor	ENSG00000128271	ADORA2A	chr22:24417879-24442360:+	Tclin	555.511
threonine synthase like 2	ENSG00000144115	THNSL2	chr2:88170295-88186636:+	Tbio	36.194
solute carrier family 30 member 6	ENSG00000152683	SLC30A6	chr2:32165841-32224379:+	Tbio	7.39564
guanylate cyclase 2F, retinal	ENSG00000101890	GUCY2F	chrX:109372906-109482072:-	Tbio	11.8984
solute carrier family 22 member 9	ENSG00000149742	SLC22A9	chr11:63369789-63410294:+	Tbio	9.83718
tousled like kinase 1	ENSG00000198586	TLK1	chr2:170990823-171231314:-	Tchem	17.1671
secretoglobin family 1D member 1	ENSG00000168515	SCGB1D1	chr11:62190216-62193539:+	Tbio	19.5
collagen type IX alpha 1 chain	ENSG00000112280	COL9A1	chr6:70215061-70303083:-	Tbio	32.8947
RB binding protein 9, serine hydrolase	ENSG00000089050	RBBP9	chr20:18486540-18497243:-	Tchem	17.3889
hyperpolarization activated cyclic nucleotide gated potassium channel 1	ENSG00000164588	HCN1	chr5:45259247-45696151:-	Tclin	109.065
5-hydroxytryptamine receptor 1F	ENSG00000179097	HTR1F	chr3:87990696-87993835:+	Tchem	18.0833
sulfatase modifying factor 1	ENSG00000144455	SUMF1	chr3:3700814-4467281:-	Tbio	58.5111
PHD finger protein 20	ENSG00000025293	PHF20	chr20:35771974-35950381:+	Tbio	26.4956
taste 2 receptor member 38	ENSG00000257138	TAS2R38	chr7:141972631-141973773:-	Tbio	145.179
chitinase domain containing 1	ENSG00000177830	CHID1	chr11:867860-915058:-	Tbio	7.09563
peptidylprolyl isomerase like 3	ENSG00000240344	PPIL3	chr2:200870907-200889303:-	Tbio	27.5921
casein alpha s1	ENSG00000126545	CSN1S1	chr4:69931081-69946574:+	Tbio	603.003
tryptophanyl tRNA synthetase 2, mitochondrial	ENSG00000116874	WARS2	chr1:119031216-119140671:-	Tbio	20.9547
fibroblast growth factor 22	ENSG00000070388	FGF22	chr19:639879-644371:+	Tbio	4.76519

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