PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
apolipoprotein FENSG00000175336APOFchr12:56360569-56362823:-Tbio21.0838
growth differentiation factor 2ENSG00000263761GDF2chr10:47322490-47326270:+Tbio67.1678
RAB9A, member RAS oncogene familyENSG00000123595RAB9AchrX:13689121-13710506:+Tbio49.9739
solute carrier family 16 member 6ENSG00000108932SLC16A6chr17:68267026-68291267:-Tdark5.18377
von Willebrand factor C domain containing 2ENSG00000188730VWC2chr7:49773661-49921950:+Tdark0.833333
ubiquitin protein ligase E3 component n-recognin 7ENSG00000012963UBR7chr14:93207056-93229215:+Tdark1.11111
signal peptide peptidase like 2AENSG00000138600SPPL2Achr15:50702266-50765808:-Tbio15.4885
solute carrier family 25 member 46ENSG00000164209SLC25A46chr5:110738136-110765161:+Tbio2.8543
potassium inwardly rectifying channel subfamily J member 1ENSG00000151704KCNJ1chr11:128836315-128867373:-Tchem178.479
sodium voltage-gated channel alpha subunit 10ENSG00000185313SCN10Achr3:38696802-38794010:-Tclin258.116
neuropeptide FF receptor 1ENSG00000148734NPFFR1chr10:70247329-70283676:-Tchem20.2095
dehydrogenase/reductase 7ENSG00000100612DHRS7chr14:60144120-60169856:-Tbio4.94583
dermcidinENSG00000161634DCDchr12:54644591-54648493:-Tbio213.07
ubiquinol-cytochrome c reductase complex assembly factor 3ENSG00000204922UQCC3chr11:62670273-62673687:+Tbio1.51111
mannosidase alpha class 2B member 1ENSG00000104774MAN2B1chr19:12646511-12666742:-Tchem48.9143
major facilitator superfamily domain containing 6ENSG00000151690MFSD6chr2:190408355-190509205:+Tbio18.439
ATP binding cassette subfamily A member 9ENSG00000154258ABCA9chr17:68974488-69061064:-Tdark2.77778
lipase family member NENSG00000204020LIPNchr10:88761406-88778242:+Tbio337.366
polypeptide N-acetylgalactosaminyltransferase 1ENSG00000141429GALNT1chr18:35581117-35711834:+Tbio29.7482
proline rich protein BstNI subfamily 2ENSG00000121335PRB2chr12:11391540-11501041:-Tbio50.5525

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