PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 25 member 25ENSG00000148339SLC25A25chr9:128068201-128109245:+Tbio3.825
phospholipase C delta 3ENSG00000161714PLCD3chr17:45108967-45133354:-Tbio14.7021
tubulin gamma 2ENSG00000037042TUBG2chr17:42659305-42667006:+Tdark2.97619
neuropeptide BENSG00000183979NPBchr17:81900745-81902905:+Tdark90.3433
inter-alpha-trypsin inhibitor heavy chain 1ENSG00000055957ITIH1chr3:52777592-52792068:+Tbio29.7815
estrogen related receptor betaENSG00000119715ESRRBchr14:76310614-76501841:+Tchem61.0886
mitogen-activated protein kinase kinase kinase 15ENSG00000180815MAP3K15chrX:19360056-19515261:-Tchem5.91667
autophagy related 4A cysteine peptidaseENSG00000101844ATG4AchrX:108091668-108154671:+Tbio8.83571
thyroid stimulating hormone subunit betaENSG00000134200TSHBchr1:115029824-115034309:+Tbio217.826
otopetrin 1ENSG00000163982OTOP1chr4:4188803-4226889:-Tbio1.86667
cholinergic receptor muscarinic 2ENSG00000181072CHRM2chr7:136868669-137020255:+Tclin285.735
alpha kinase 3ENSG00000136383ALPK3chr15:84816680-84873482:+Tdark7
eosinophil peroxidaseENSG00000121053EPXchr17:58192737-58205174:+Tbio345.209
protein tyrosine phosphatase receptor type QENSG00000139304PTPRQchr12:80402178-80680234:+Tbio15.5083
vesicle associated membrane protein 7ENSG00000124333VAMP7chrX:155881293-155943769:+Tbio65.8103
DnaJ heat shock protein family (Hsp40) member C16ENSG00000116138DNAJC16chr1:15526813-15592379:+Tdark0
FKBP prolyl isomerase 15ENSG00000119321FKBP15chr9:113161006-113221361:-Tdark7.73571
dehydrogenase/reductase 4 like 2ENSG00000187630DHRS4L2chr14:23969874-24006408:+Tdark1.33333
interferon alpha 1ENSG00000197919IFNA1chr9:21409169-21441316:+Tbio1.03535
solute carrier family 25 member 38ENSG00000144659SLC25A38chr3:39383348-39397351:+Tbio12.9174

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